Spazgan - instructions for use, analogues, reviews and release forms (tablets, injections in ampoules for injections in solution) of a drug for the treatment of headaches and during menstruation in adults, children and pregnancy and alcohol

In this article, you can read the instructions for using the drug Spazgan. Provides feedback from visitors to the site - consumers of this medicine, as well as the opinions of medical specialists on the use of Spazgan in their practice. A big request is to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, possibly not announced by the manufacturer in the annotation. Spazgan analogs in the presence of existing structural analogues. Use for the treatment of joint pain, headache and during menstruation in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Spazgan - a combined analgesic and antispasmodic, a combination of the components of the drug leads to a mutual strengthening of their pharmacological action.

Metamizole sodium - a derivative of pyrazolone, has an analgesic and antipyretic effect.

Pitophenone hydrochloride has a direct myotropic effect on smooth muscle (papaverin-like action).

Fenpiverinia bromide has an m-anticholinergic effect and has an additional myotropic effect on smooth muscles.

Composition

Metamizole sodium + Pitophenone hydrochloride + Fenpiverinium bromide + excipients.

Indications

Pain syndrome (mild or moderate) with spasms of smooth muscles of internal organs:

  • renal colic,
  • spasm of the ureter and bladder,
  • biliary colic
  • intestinal colic
  • biliary dyskinesia,
  • postcholecystectomy syndrome,
  • chronic colitis
  • algodismenorea,
  • diseases of the pelvic organs.

For short-term treatment:

As an auxiliary drug:

  • pain after surgery and diagnostic procedures.

Release Forms

Solution for intravenous and intramuscular administration (injections in ampoules for injection).

Instructions for use and dosage regimen

Inside: adults and adolescents over 15 years: 1-2 tablets 2-3 times a day, without chewing, with a small amount of liquid.

Children 12-14 years: a single dose - 1 tablet, the maximum daily dose - 6 tablets (1.5 tablets 4 times a day), 8-11 years old - 0.5 tablets, the maximum daily dose - 4 tablets (1 tablet 4 times a day) , 5-7 years - 0.5 tablets, the maximum daily dose - 2 tablets (0.5 tablets 4 times a day).

Parenteral (intravenous, intramuscular).

Adults and adolescents over 15 years of age with acute severe colic are injected iv slowly (1 ml for 1 min), 2 ml each, if necessary, re-administered after 6-8 hours. I / m - 2-5 ml of a solution of 2-3 once a day. The daily dose should not exceed 10 ml. The duration of treatment is no more than 5 days.

Calculation of the dose for children with intravenous and intramuscular administration: 3-11 months (5-8 kg) - only IM - 0.1-0.2 ml, 1-2 years (9-15 kg) - IV - 0.1-0.2 ml , in / m - 0.2-0.3 ml, 3-4 years (16-23 kg) - in / in - 0.2-0.3, in / m - 0.3-0.4 ml, 5-7 years (24-30 kg) - / in - 0.3-0.4 ml, in / m - 0.4-0.5 ml, 8-12 years (31-45 kg) - in / in - 0.5-0.6 ml, in / m - 0.6-0.7 ml, 12-15 years - in / in and / m - 0.8-1 ml.

Before the injection, it should be warmed in the hand.

Side effect

  • urticaria (including on the conjunctiva and mucous membranes of the nasopharynx),
  • angioedema,
  • malignant exudative erythema (Stevens-Johnson syndrome),
  • toxic epidermal necrolysis (Lyell syndrome),
  • bronchospastic syndrome,
  • anaphylactic shock,
  • impaired renal function,
  • oliguria, anuria, proteinuria,
  • interstitial nephritis,
  • staining urine in red,
  • decrease in blood pressure,
  • thrombocytopenia, leukopenia, agranulocytosis (may manifest the following symptoms: unmotivated fever, chills, sore throat, difficulty swallowing, stomatitis, as well as the development of vaginitis or proctitis),
  • dry mouth
  • reduced sweating
  • tachycardia,
  • difficulty urinating
  • with intramuscular administration, infiltrates at the injection site are possible.

Contraindications

  • hypersensitivity (including to pyrazolone derivatives),
  • inhibition of bone marrow hematopoiesis,
  • severe hepatic and / or renal failure,
  • glucose-6-phosphate dehydrogenase deficiency,
  • tachyarrhythmias,
  • severe angina pectoris,
  • decompensated chronic heart failure,
  • angle-closure glaucoma,
  • prostatic hyperplasia (with clinical manifestations),
  • intestinal obstruction,
  • megacolon
  • collapse,
  • pregnancy (especially in the first trimester and in the last 6 weeks),
  • lactation
  • for intravenous administration - infancy (up to 3 months) or body weight less than 5 kg. For tablets - children's age (up to 5 years).

Pregnancy and lactation

Spazgan is contraindicated in pregnancy (especially in the first trimester and in the last 6 weeks).

Use in nursing mothers requires termination of breastfeeding.

Use in children

Contraindications for intravenous administration are infant age (up to 3 months) or body weight less than 5 kg, for tablets - children's age (up to 5 years).

Treatment of children under 5 years of age should be carried out only under the supervision of a doctor.

special instructions

During the period of treatment with the drug, it is not recommended to take ethanol (alcohol).

With prolonged (more than a week) treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver.

If you suspect agranulocytosis or in the presence of thrombocytopenia, you must stop taking the drug.

It is unacceptable to use for relief of acute abdominal pain (until the cause is clarified).

Intolerance is very rare, but the threat of anaphylactic shock after intravenous administration of the drug is relatively higher than after taking the drug inside. Patients with atopic bronchial asthma and pollinosis have an increased risk of allergic reactions.

Parenteral administration should be used only in cases where oral administration is not possible (or absorption from the gastrointestinal tract is impaired). Particular care is required when introducing more than 2 ml of solution (risk of a sharp decrease in blood pressure). Intravenous injection should be carried out slowly, in a prone position and under the control of blood pressure, heart rate and BH.

When treating children under 5 years old and patients receiving cytostatics, metamizole sodium should be administered only under medical supervision.

For intramuscular administration, a long needle must be used.

It is possible to stain urine in red due to the release of the metabolite (it does not have clinical significance).

Influence on the ability to drive vehicles and control mechanisms

During treatment, caution should be exercised by drivers of vehicles and persons engaged in potentially hazardous activities that require quick physical and mental reactions.

Overdose

Symptoms: vomiting, decreased blood pressure, drowsiness, confusion, nausea, pain in the epigastric region, impaired liver and kidney function, convulsions.

Treatment: gastric lavage, the appointment of activated carbon, symptomatic therapy.

Drug interaction

Solution for injection is pharmaceutically incompatible with other drugs.

When combined with histamine and H1-blockers, butyrophenones, phenothiazines, tricyclic antidepressants, amantadine and quinidine, an increase in m-anticholinergic action is possible.

Enhances the effects of ethanol (alcohol), simultaneous use with chlorpromazine or other phenothiazine derivatives can lead to the development of severe hyperthermia.

Tricyclic antidepressants, oral contraceptives and allopurinol increase the toxicity of the drug.

Phenylbutazone, barbiturates, and other inducers of hepatic enzymes while concomitantly decreasing the effectiveness of metamizole sodium.

Sedative and anxiolytic drugs (tranquilizers) enhance the analgesic effect of metamizole sodium.

X-ray contrast drugs, colloidal blood substitutes, and penicillin should not be used during treatment with drugs containing metamizole sodium.

With the simultaneous administration of cyclosporine, the concentration of the latter in the blood decreases.

Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids (GCS) and indomethacin, can increase the severity of their action.

Tiamazole and cytostatics increase the risk of developing leukopenia.

The effect is enhanced by codeine, H2-histamine receptor blockers and propranolol (slows the inactivation of metamizole sodium).

Analogs of the drug Spazgan

Structural analogues of the active substance:

Release form, composition and pharmacological action

The medication combines the properties of an analgesic and antispasmodic, that is, it allows you to stop pain and get rid of muscle cramps, relaxing smooth muscles. In addition, it provides a certain anti-inflammatory effect in case of fever and other pathological conditions.

The main properties of the drug are due to the presence of:

  • metamizole sodium (non-narcotic analgesic),
  • fenpiverinia bromide,
  • pitophenone hydrochloride (antispasmodic).

It can be produced in the form of tablets placed in the cells of contour packaging, or in ampoules as a solution for injection (both intravenous and intramuscular).

Indications and contraindications

The tool is used for:

  • dyskinetic pathologies of the gastrointestinal tract, gall bladder and its ducts,
  • joint pain syndromes,
  • lumbosacral radiculitis,
  • pain caused by muscle hypertonicity,
  • unspecified neuralgia, neuritis, renal colic, dysmenorrhea and other spastic manifestations, pain in the gastrointestinal tract,
  • spasmodic and convulsive manifestations,
  • fever caused by colds and infectious diseases,
  • complications arising from surgical and therapeutic effects,
  • renal and biliary colic,
  • pathologies affecting the pelvic organs.

However, Spazgan has a number of contraindications:

  • excessive sensitivity to the substances that make up the drug,
  • severe problems in the kidneys and liver,
  • lack of glucose-6-phosphate dehydrogenase, due to the genetic characteristics of the patient,
  • tachycardia,
  • angle-closure glaucoma,
  • hypertrophied prostate gland, which caused regular urinary retention,
  • gastrointestinal obstruction,
  • hematopoietic system diseases
  • the first trimester and the last 1.5 months of the gestation period,
  • lactation,
  • age up to 5 years if tablets are used, or up to 3 months (up to 5 kg) - when performing injections,
  • conditions characterized by depression of the central nervous system,
  • malformation of the colon (its increase).

In the presence of renal or hepatic insufficiency, arterial hypotension and its location, bronchial asthma, urticaria, rhinitis (due to NSAIDs), the patient should also be careful.

Spazgan in tablet form is preferably used after eating according to the scheme shown in the table.

Age groups (years)
The number of tablets drunk in 1 dose
from 151 - 2 (no more than 6 tablets per day)
13 – 151
9 – 12¾
6 – 8½

The number of medications for patients of all ages: 2-3 times a day. The duration of the therapeutic course is 5 days. Changes in the dosage and general course of treatment can only be carried out after consulting with a specialist.

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Spazgan ampoules: instructions for the use of injections

The dosage of Spazgan for intramuscular (IM) and intravenous (IV) administration is also determined by the age of the patient.

Age (years)
Reception schedule
from 15If we are talking about colic of significant severity, then the solution must be administered iv in extremely slowly (1 ml / min, only 2 ml). An additional injection is done no earlier than after 6-8 hours.
With the intramuscular injection of Spazgan, the volume of one dose increases to 2-5 ml, and injections can be done 2-3 times a day. However, the total amount administered per day should not exceed 10 ml.
12 - 15 (from 45 kg.)For both types of injections - 0.8-1 ml of the drug.
8 - 12 (from 31 kg.)In / in - 0.5-0.6 ml.
V / m - 0.6-0.7 ml.
5 - 7 (from 24 kg.)In / in - 0.3-0.4 ml, and 0.4-0.5 - in / m.
3 - 4 (from 16 kg.)In / in - 0.2-0.3 ml, and / m - 0.3-0.4 ml.
1 - 2 (from 9 kg.)At 0.1-0.2 ml iv and 0.2-0.3 ml iv.
3 - 11 months (from 5 kg)Only v / m injections of the drug are allowed at 0.1-0.2 ml at a time.

The duration of the therapeutic course is determined by the symptoms and etiopathogenesis, however, it cannot last more than 5 days.

IMPORTANT: The solution used for administration should not be cold. To avoid this, you just need to hold an unsolved ampoule in your hand for a while, warming it.

The use of Spazgan in the first 3 and last 1.5 months of pregnancy, as well as during the lactation period, is prohibited.

Side effects, overdose

Taking the drug in the doses prescribed by the instruction allows you to avoid almost any side effects. In rare cases, it is noted:

  • allergic symptoms (feelings of itching, rashes on the skin, in exceptional situations - anaphylactic shock),
  • burning sensation, covering the epigastric region,
  • headaches and dizziness,
  • dry mouth
  • lowering blood pressure
  • the appearance of disorders affecting the blood system (their appearance is due to prolonged use of the drug),
  • toxic epidermal necrolysis,
  • attacks of bronchospasm (in the presence of an initial predisposition to this),
  • angioedema,
  • Escudative erythrem
  • unreasonable increase in temperature,
  • difficulty swallowing
  • Wanigitis and proctitis,
  • disturbances in the functioning of the urinary system and kidneys (also urine can turn red),
  • the appearance of infiltrates at the injection site with intramuscular injection of the drug.

In case of an overdose, among the most pronounced symptoms are:

  • feeling of nausea and vomiting,
  • too low body temperature and a drop in blood pressure,
  • cardiopalmus,
  • acute failure (hepatic and renal),
  • bouts of shortness of breath and seizures,
  • feeling sleepy
  • pain in the stomach (cramping type),
  • delusions and distortions in the work of consciousness,
  • respiratory muscle paralysis,
  • hemorrhagic syndromes.
  1. If any of these signs are detected, you should immediately stop taking the medication and seek help from a specialist.
  2. With any options for combined medication, you should get a preliminary consultation with a doctor.
  3. It is advisable not to combine the drug with other non-narcotic analgesics, as this can cause an increase in their toxic effects on the body.

In the case of combination with tricyclic antidepressants, allopurinol, or contraceptives, it is possible to provoke a violation of metabolic processes (production of metamizole) in the liver and increased Spazgan toxicity. When using phenylbutazone, barbiturates and similar substances, metamizole is less effective.

  • Cyclosporin is not effective enough in combination with Spazgan.
  • Combinations with tranquilizers and sedatives can enhance the analgesic effect.
  • If we are talking about an injection solution, then its compatibility with other drugs is zero.

Special instructions

If we are talking about the treatment of patients suffering from hypotension, bronchospasm, impaired liver and kidney function, then the drug is taken exclusively under the guidance and supervision of a treating specialist. The same applies to persons with hypersensitivity to the components of the drug.

When using Spazgan for more than 7 days, it is necessary to monitor the parameters of peripheral blood tests and liver function. If thrombocytopenia was diagnosed during therapy or a risk of agranulocytosis is found, then the medication is stopped.

Using Spazgan is also inappropriate until a diagnosis is made and the exact cause of the pain is identified.

During the injection, it is necessary to control the heartbeat, blood pressure and respiratory rate. You also need to be careful when introducing more than 2 ml of the drug into the body (this can lead to a significant drop in blood pressure).

During treatment, psychomotor reactions slow down, so drivers and workers involved in potentially hazardous activities should be very careful.

The price of the drug Spazgan, its analogues

In terms of cost, Spazgan is not very different from most similar drugs, which can be identified by studying the table below.

Drug name
Release form
Cost, rub.)
Spazgantablets (20 and 100 pieces per pack)91 – 450
Spazganampoules with a solution for intravenous and intramuscular injection (5 pieces of 5 ml)93 – 111
Greasetablets (10, 20 or 50 pieces per pack)100 – 320
Spazmalgonampoules with a solution for i / m administration (10 pieces of 2 or 5 ml)243 – 337
Tooktablets (10, 20 or 100 pieces per pack)39 – 266
Tookampoules with a solution for intravenous and intramuscular administration (5 pieces of 5 ml)118 – 122
Spasm blocktablets (20 pieces per pack)98 – 128

In individual drugstores, the cost of drugs may differ, but slightly.

Reviews

Spazgan is used very widely. If you follow the instructions supplied with the tool, there are no problems with the use of the medication. For this reason, reviews from people who have felt its effect on themselves are mostly positive.

For several years in a row, in the midst of autumn and spring, you have to buy Spazgan to relieve spasm-like pain in your temples.

Four years ago, I had problems with vessels in the neck (near the spine), which is why my head hurts. I cannot completely recover my health, but I can take a pill and the attack goes away.

At the moment, this is the only proven and inexpensive way to get rid of unnecessary torment.

Mikhail, 38 years old, St. Petersburg

I have a hard time during menstruation. Previously, the condition was terrible, I could not even get out of bed during this period. I tried a couple of other drugs, but did not feel much relief.

Then the turn came to Spazgan, and it turned out to be a good choice.

Although once I went too far and my blood pressure dropped a lot, but this was an isolated case and it has nothing to do with the quality of the pills.

Olga, 29 years old, Samara

It is very convenient that these pills are dispensed without a prescription, but I do not use them as often. To be more precise, they perfectly suit me as a means of recovery after any alcoholic party - the pain goes away, the body relaxes. He begins to want to sleep, and this is the best way to come to his senses.

Natalia, 31 years old, Anapa

Based on these opinions, we can conclude that the drug is truly effective. However, it has an acceptable cost and its presence in a home medicine cabinet is quite appropriate.

You can learn some more information about Spazgan from the next video.

Spazgan: pills and injections - updated 03.19

In this medical article, you can find the drug Spazgan. Instructions for use will explain in which cases you can take injections or tablets, what the medicine helps, what indications there are for use, contraindications and side effects. The annotation presents the form of the drug and its composition.

Anesthetic and antispasmodic drug belonging to the pyrazolone group is Spazgan. Instructions for use indicate that tablets, injections in ampoules for injection in solution have antipyretic and anti-inflammatory effects.

Release form and composition

Spazgan is available in the form of tablets for oral administration and a solution for injections.

Round tablets, white with a risk on one side, are produced in blisters of 10 pieces, 1-5 blisters in a cardboard box with the attached detailed instructions. Tablets and solution contain active active ingredients:

  • metamizole sodium
  • pitofen hydrochloride,
  • fenpiverinium bromide.

The solution for injection is available in 5 ml brown glass ampoules. Ampoules are laid out in plastic pallets of 10 pieces in a cardboard box with the attached instructions.

Pharmachologic effect

Metamizole sodium is a non-narcotic analgesic that has pronounced analgesic and antipyretic properties. In addition, this component has a weak anti-inflammatory effect. The pitophenone included in the composition acts on the smooth muscles of the internal organs, causing it to relax.

Fenpiverinium acts as an anticholinergic component that further relaxes smooth muscles. Spazgan is an effective drug that relieves pain and reduces fever.

Indications for use

What helps Spazgan? Tablets and injections are prescribed:

  • decrease in increased body temperature in patients with colds or infectious and inflammatory diseases,
  • reduction of pain after surgical or diagnostic procedures.

Indications for the use of Spazgan with mild to moderate pain is:

  • dysmenorrhea
  • biliary or renal colic,
  • spastic condition of internal organs,
  • symptomatic treatment for neuralgia, myalgia, sciatica,
  • intestinal cramps
  • joint pain.

Attention! Do not use the drug to stop abdominal pain until the cause of its occurrence is clarified.

Spazgan tablets

  • Adults and adolescents over 15 years of age: 1-2 tablets 2-3 times a day, without chewing, with a small amount of liquid.
  • Children 12-14 years: a single dose - 1 tablet, the maximum daily dose - 6 tablets (1.5 tablets 4 times a day).
  • 8-11 years old - 0.5 tablets, the maximum daily dose - 4 tablets (1 tablet 4 times a day).
  • 5-7 years - 0.5 tablets, the maximum daily dose - 2 tablets (0.5 tablets 4 times a day).

Composition and form of release

Tablets1 tab.
metamizole sodium500 mg
pitophenone hydrochloride5 mg
fenpiverinia bromide0.1 mg

in blister packs of 10 pieces, in a box of 2 or 10 packs.

In which case spazgan is ineffective

The only situation where the use of spazgan does not make sense is headaches caused by high blood pressure. Given the fact that the composition of the drug in question does not include any of the antihypertensive drugs, its purpose can be justified only for the purpose of short-term relief of the pain syndrome.

In parallel with spazgan, it will be necessary to inject Magnesium Sulphate 25% to reduce blood pressure.

In addition, the appointment of the drug in question should not be recommended if the patient has an attack of abdominal pain (in simple terms, the stomach hurts). Especially in the case of acute dagger pain that occurs in the lower abdomen or in the epigastrium.

This is because in the described situation, the pain may have an inflammatory origin (in other words, the etiological factors of this condition are acute inflammatory processes in the abdominal cavity - cholecystitis, pancreatitis or appendicitis). If pain is noted in the upper sections, then most likely the cause of the pain will be a perforated stomach ulcer.

It cannot be said that in the above cases, the appointment of a spazgan will be ineffective. It just works, but its effect will be on the contrary, extremely undesirable. In this case, only surgery will be indicated, but not drug treatment. So with such symptoms, urgent hospitalization in a surgical hospital will be necessary.

Is it possible to prescribe spazgan for yourself? Will there be harm from ongoing self-medication?

You can not drink this drug only for children and during pregnancy. In all other cases, the use of spazgan can be carried out without prior consultation of the attending physician. Spazgan headache pills instructions for use are included in the package.

Indications for use - all the same as for non-steroidal anti-inflammatory drugs, as well as for spasmolytics (all recommendations are determined by the composition of the combined drug). An important advantage of it is also a prolonged shelf life, so you can buy spazgan and put it in a home medicine cabinet on demand.

Ampoules

Parenteral (intravenous, intramuscular). Adults and adolescents over 15 years of age with acute severe colic are injected iv slowly (1 ml for 1 min), 2 ml each, if necessary, re-administered after 6-8 hours.

V / m - 2-5 ml of the solution 2-3 times a day. The daily dose should not exceed 10 ml. The duration of treatment is no more than 5 days. Calculation of the dose for children with intravenous and intramuscular administration:

  • 3-11 months (5-8 kg) - only in oil - 0.1-0.2 ml,
  • 1-2 years (9-15 kg) - in / in - 0.1-0.2 ml, in / m - 0.2-0.3 ml,
  • 3-4 years (16-23 kg) - in / in - 0.2-0.3, in / m - 0.3-0.4 ml,
  • 5-7 years (24-30 kg) - in / in - 0.3-0.4 ml, in / m - 0.4-0.5 ml,
  • 8-12 years (31-45 kg) - in / in - 0.5-0.6 ml, in / m - 0.6-0.7 ml,
  • 12-15 years - in / in and / m - 0.8-1 ml.

Before the injection, it should be warmed in the hand.

Read also this article: Trental injections, tablets: instructions, price, analogues and reviews

List of main medical contraindications

The list of contraindications for the use of Spazgan is extensive. It cannot be used in the following cases:

  • With heart failure
  • Angina pectoris, tachycardia, tachyarrhythmias,
  • Impaired liver and kidney function,
  • Inhibition of bone marrow hematopoiesis,
  • Glaucoma, cataracts,
  • Intestinal obstruction,
  • Intolerances included in the main and auxiliary components of the drug.

Spazgan is prohibited during childbearing and breastfeeding, because its clinical trials in pregnant women have never been conducted. During this period, you can use other painkillers with a delicate gentle effect on the fetus.

With abdominal pain of an incomprehensible etiology, one should not take any painkillers at all. This rule is the same for all patients. The drug acts on the receptors of the brain, blocking them.

If the patient is no longer experiencing pain, it is more difficult for the doctor to examine him, to diagnose. He can make a mistake and make the wrong diagnosis. Painkillers are used after determining the cause and localization of discomfort.

Contraindications

  • severe renal or hepatic impairment,
  • inhibition of bone marrow hematopoiesis,
  • prostatic hyperplasia (with clinical manifestations),
  • hypersensitivity to pyrazolone derivatives,
  • individual intolerance to the components of the drug,
  • angle-closure form of glaucoma,
  • glucose-6-phosphate dehydrogenase deficiency,
  • intestinal obstruction, megacolon,
  • decompensation stage of chronic heart failure,
  • unstable and stable angina,
  • period of pregnancy and breastfeeding,
  • tachyarrhythmias.

  • solution: acute intermittent porphyria, collapse, age up to 3 months of life or body weight up to 5 kg,
  • tablets: granulocytopenia, lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome, age up to 8 years.

Components of the drug and pharmacological action

The composition of Spazgan contains three active components:

  • Pitophenone hydrochloride -, which predominantly acts on smooth muscles. The substance exerts a more pronounced effect on the layer of smooth myocytes of internal organs.
  • Metamizole sodium is a non-narcotic analgesic from the pyrazolone group. The main action is aimed at blocking the activity of the enzyme that synthesizes prostaglandin. In turn, a lack of prostaglandin reduces tissue sensitivity to bradykinin, a substance that activates pain receptors. The analgesic has analgesic, moderate anti-inflammatory and antipyretic effects.
  • Fenpiverinia bromide is an M-anticholinergic drug that blocks parasympathetic nerve impulses into the smooth muscles of internal organs. Thanks to its action, peristalsis and tone of all internal systems are reduced, which is manifested by an increase in analgesic and antispasmodic effects.

The main advantage of the product is its multicomponent nature. The components of Spazgan potentiate each other's actions, which ensures the severity of the pharmacological effect on the body.

Pharmacodynamics

The composition of the drug includes: non-narcotic analgesic - metamizole sodiummyotropic antispasmodic - pitophenone hydrochloride and anticholinergics - fenpiverinia bromide. Metamizole is a pyrazolone derivative. It has analgesic, antipyretic and mild anti-inflammatory effects.

Pitophenone, like papaverine, has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation.

Fenpiverinium due to anticholinergic action has an additional relaxing effect on smooth muscles. The combination of the three components of the drug leads to a mutual strengthening of their pharmacological action, expressed in pain relief, relaxation of smooth muscles, and a decrease in elevated body temperature.

Interaction with other drugs

The simultaneous administration of Spazgan and antihistamines enhances the action of the main substance. Sedative drugs, tranquilizers do not combine with Spazgan, because in patients with this, blood pressure is even lower. You can not take the drug with alcohol or ethanol-based drugs.

To avoid the occurrence of side effects due to non-compliance with the rules for the interaction of various drugs, you must strictly adhere to the advice of your doctor and never self-medicate. Self-controlled uncontrolled administration of analgesics can lead to negative consequences with a long recovery period and irreversible conditions.

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Joint administration with non-narcotic analgesic drugs increases the risk of negative reactions, as

there is an increase in the pharmacological activity of drugs.

NSAIDs, allopurinol, tricyclic antidepressants, codeine, H2-histamine receptor inhibitors, contraceptives and propranolol disrupt the drug metabolism, increasing its toxic effect with the development of adverse reactions.

Derivatives of barbituric acid, phenylbutazone reduce the pharmacological effect of Spazgan.

Parallel administration of Spazgan and tranquilizers or sedatives causes potentiation of the analgesic effect of the drug.

H1 blockers of histamine receptors, tricyclic antidepressants, amantadine, quinidine enhance the M-anticholinergic effect of Spazgan.

Simultaneous use with ethanol causes potentiation and amplification of each other's effects.

Derivatives of phenothiazine, chlorpromazine with parallel treatment with Spazgan can provoke hyperpyrexia.

X-ray contrast agents, colloidal blood substitutes, penicillin are not used in the treatment of Spazgan.

Spazgan enhances the pharmacological activity of hypoglycemic oral agents, GCS, indomethacin, and indirect anticoagulants.

Injection is not compatible with any other medicines.

Pharmacokinetics

After oral administration, metamizole sodium is rapidly absorbed from the digestive tract. In the intestinal wall is hydrolyzed with the formation of an active metabolite. Unchanged metamizole sodium in the blood is not determined (only after iv administration is detected in the blood plasma in low concentrations and quickly becomes unavailable for determination). After i / m administration, the active substances of the drug are rapidly and substantially absorbed from the injection site.

Binding to plasma proteins is 50-60%. When taken in therapeutic doses, excreted in breast milk.

Metamizole sodium undergoes intensive biotransformation in the liver. The main metabolites are 4-methylaminoantipyrine, 4-formylaminoantipyrine, 4-aminoantipyrine and 4-acetylaminoantipyrine. About 20 additional metabolites have been identified, including derivatives of glucuronic acid. The main four metabolites are found in cerebrospinal fluid. It is excreted mainly by the kidneys.

Quickly absorbed from the gastrointestinal tract when taken orally. C max in blood plasma is reached after 30-60 minutes. It is quickly distributed in organs and tissues, does not penetrate the BBB.

It is metabolized in the liver by oxidative reactions. It is excreted in the urine. T 1/2 is 1.8 hours

When taken orally, it is rapidly absorbed from the digestive tract. C max in blood plasma is reached within 1 h. Does not penetrate the BBB. It is excreted unchanged with urine 32.4-40.4%, with bile - 2.3-5.3%.

Indications of the drug Spazgan ™

Mild or moderate pain syndrome with spasms of smooth muscles of internal organs:

renal and biliary colic,

dysmenorrhea and other spastic conditions of internal organs,

short-term symptomatic treatment for pain in the joints, neuralgia, sciatica, myalgia,

as an aid to reduce pain after surgical and diagnostic procedures,

to reduce elevated body temperature with colds and infectious and inflammatory diseases.

Composition:

1 ml of solution contains:

active substances:
metamizole sodium (analgin)- 500 mg
pitophenone hydrochloride- 2 mg
fenpiverinia bromide- 0.02 mg
Excipients:
water- up to 1.0 ml

Description

Transparent, colorless or light yellow liquid.

Dosage and administration

Spazgan, injection, is used only intramuscularly.

Intramuscularly injected from 2 to 5 ml of a solution for injection. If necessary, the dose is repeated after 6-8 hours. The maximum daily dose should not exceed 10 ml of solution for injection (equivalent to 5 g of metamizole sodium). The duration of treatment is 2-3 days. After achieving a therapeutic effect, you can switch to treatment with oral painkillers and antispasmodics. In the absence of a therapeutic effect, treatment should be discontinued.

Adverse reactions

Allergic reactions: skin rash, urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), itching rarely - angioedema, anaphylactic shock, in rare cases - toxic epidermal necrolysis (Lyell syndrome), Stevens-Johnson syndrome, hemorrhage.

From the digestive tract: discomfort, burning in the epigastric region, dry mouth, constipation, exacerbation of gastritis and gastric ulcer.

From the side of the central nervous system: headache, dizziness.

From the side of the organ of vision: visual disturbances, disturbances of accommodation.

From the cardiovascular system: arterial hypotension, tachycardia, cardiac arrhythmias.

From the respiratory system: bronchospasm.

From the urinary system: impaired renal function, oliguria, anuria, proteinuria, red staining of urine, interstitial nephritis, urinary retention, difficulty urinating, development of acute renal failure, polyuria.

On the part of the blood: anemia, granulocytopenia, leukopenia, thrombocytopenia, agranulocytosis (may manifest the following symptoms: unmotivated fever, chills, sore throat, stomatitis, development of vaginitis or proctitis).

Others: decreased sweating.

Local reactions: possible infiltrates at the injection site.

Pharmacological properties

Spazgan - a combined drug, which includes: non-narcotic analgesic metamizole sodium (analgin), myotropic antispasmodic pitophenone hydrochloride and M-anticholinergic agent fenpiverinia bromide.
Metamizole It has analgesic, antipyretic and mild anti-inflammatory effects. Pitophenone like papaverine, it has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation. Fenpiverinia bromide due to the M-anticholinergic effect, it has an additional antispasmodic effect on smooth muscles.

Side effects

Subject to the dosage prescribed by the doctor, the drug is well tolerated. Persons with individual hypersensitivity may experience side effects:

  • from the hemopoietic organs: thrombocytopenia, leukopenia,
  • from the nervous system: dizziness, lethargy, drowsiness,
  • from the organs of the urinary system: impaired renal function, decreased daily urine, anuria, proteinuria, discoloration of urine,
  • allergic reactions: angioedema, urticaria, skin rash, dermatitis, anaphylaxis,
  • from the organs of the gastrointestinal tract: severe thirst, nausea, pain in the epigastrium, vomiting, bloating, constipation,
  • on the part of the cardiovascular system: lowering blood pressure, palpitations, shortness of breath, weak pulse, cyanosis (cyanosis of the skin and mucous membranes).

When the drug is administered intramuscularly or intravenously, a burning sensation, tissue swelling, hematoma, and the formation of infiltrate appear at the injection site.

Overdose

Symptoms In case of an overdose, symptoms of metamizole intoxication in combination with anticholinergic effects predominate. Most often, there is a toxic-allergic syndrome, symptoms of damage to the hematopoiesis, gastrointestinal disorders, in severe cases - symptoms of brain damage. Possible vomiting, dry mouth, nausea, pain in the epigastric region, decreased sweating, impaired accommodation, arterial hypotension, drowsiness, confusion, impaired liver, kidney, convulsions.

Treatment. If you suspect an overdose, you should immediately stop using the drug and take measures to remove it from the body as soon as possible (forced diuresis, infusion of water-salt solutions, if necessary - hemodialysis, peritoneal dialysis). SPECIAL. There is no specific antidote.

Spazgan price in pharmacies today

If you do not manifest negative reactions as a result of taking Spazgan, then it is recommended that you “in any case” have it in your medicine cabinet. Especially if you suffer from ailments manifested by acute-onset pains.

In the absence of the drug in pharmacies (in the nearest), then in this case, you can pay attention to the analogues of the drug.A specialist pharmacist himself can offer this solution to the problem of lack of medication, however, when choosing an anesthetic drug, it is worth remembering that he has his own warnings while taking and contraindications

  • Baralgetas (Baralgetas),
  • Baralgine (Baralgin),
  • Maxigan (Maxigan),
  • Realgin (Realgin),
  • Renalgan (Renalgan),
  • Renalgan-Biolek (Renalgan-Biolek),
  • Reonalgon (Reonalgon),
  • Spasmadon (Spazmadon),
  • Spasmalgon (Spazmalgon),
  • Spasmil-M (Spazmil-M),
  • Spasmoblok (Spazmoblok),
  • Baralginus (Baralginus),
  • Baralginus-Credofarm (Baralgshinus-Kredofarm),
  • Bral
  • Spasmogard
  • Trinalgine (Trinalgin),
  • Ciclopar (Cyclopar).

The cost of Spazgan is an average of 171 rubles. Prices range from 45 to 520 rubles.

Dosage

Adults and adolescents over 15 years: 1-2 tablets. 2-3 times / day, without chewing, washing down with a small amount of liquid.

Children aged 12-14 years: a single dose - 1 tab., The maximum daily dose - 6 tab. (1.5 tab. 4 times / day), children aged 8-11 years - 0.5 tab., The maximum daily dose - 4 tab. (1 tab. 4 times / day), for children aged 5-7 years - 0.5 tab., the maximum daily dose - 2 tab. (0.5 tab. 4 times / day).

Parenteral (iv, i / m)

Adults and adolescents over 15 years of age with acute severe colic are injected iv slowly (1 ml for 1 min), 2 ml each, if necessary, re-administered after 6-8 hours. I / m - 2-5 ml of a solution of 2-3 times / day The maximum daily dose should not exceed 10 ml (which corresponds to 5 g of metamizole sodium).

The duration of the course of treatment is determined depending on the clinical symptoms and etiopathogenesis of the disease, but should not exceed 5 days.

Calculation of the dose for children with i / v and / m introduction: 3-11 months (5-8 kg) - only i / m - 0.1-0.2 ml, 1-2 years (9-15 kg) - i / v - 0.1-0.2 ml, i / m - 0.2-0.3 ml, 3-4 years (16-23 kg) - i / v - 0.2-0.3, i / m - 0.3-0.4 ml, 5-7 years (24-30 kg) - in / in - 0.3-0.4 ml, in / m - 0.4-0.5 ml, 8-12 years (31-45 kg) - in / in - 0.5-0.6 ml, in / m - 0.6-0.7 ml, 12-15 years - in / in and / m - 0.8-1 ml.

Before the injection, it should be warmed in the hand.

Indications for use

Pain with spasms of smooth muscles of internal organs including: renal colic, hepatic colic, biliary colic, intestinal colic, biliary dyskinesia, algomenorrhea.
For short-term symptomatic treatment: arthralgia, neuralgia, myalgia, sciatica.
As an adjuvant: pain after surgery and diagnostic procedures.

Application features

When using Spazgan, there is a risk of anaphylactic reactions (anaphylactic shock). At the first signs of hypersensitivity reactions, the use of the drug should be discontinued and appropriate measures should be taken to improve the condition (using adrenaline, glucocorticoids, antihistamines). The risk of hypersensitivity reactions in people with food and drug sensitivity or with atopic diseases (hay fever, hay fever, bronchial asthma) is increased.

Caution should be exercised when administering more than 2 ml of the solution (risk of a sharp decrease in blood pressure).

A long needle should be used for insertion.

The drug should be used with caution in patients with obstructive diseases of the digestive tract (achalasia, pyloroduodenal stenosis). Repeated use of the drug in these cases can cause a delay in the gastrointestinal contents and intoxication.

With caution and under the supervision of a doctor, it is used in case of impaired renal function (pyelonephritis, glomerulonephritis) and / or liver, in patients with impaired hematopoiesis, intestinal atony, paralytic ileus, glaucoma, myasthenia gravis, with a tendency to hypotension and orthostatic reactions, in the presence of hyperthyroidism, with chronic bronchitis, with arrhythmias, coronary heart disease (especially with acute myocardial infarction), chronic congestive heart failure.

In diseases of the kidneys and liver, the dosage regimen should be selected individually due to possible side effects of metamizole on the kidneys and lengthening the half-life of metamizole metabolites in case of impaired hepatocyte function.

In the treatment of metamizole, there is a risk of agranulocytosis.The development of agranulocytosis is not dose dependent and cannot be predicted. It can develop after repeated use. When treating patients with hematological diseases or having a history of the drug, the risk / benefit ratio should be assessed and the hematological status monitored during treatment. If you suspect agranulocytosis or in the presence of thrombocytopenia, you should stop using the drug.

You can not use the drug to stop abdominal pain (until the cause is clarified).

With prolonged (more than 1 week) use of the drug, it is necessary to control the picture of peripheral blood and the functional state of the liver.

The drug can affect the psychophysical state of patients while using alcohol and drugs that suppress the central nervous system.

To prevent the risk of overdose, you should carefully check the content of metamizole in other drugs that are prescribed simultaneously with the drug Spazgan.

With prolonged use of the drug, its anticholinergic effect can lead to dizziness or impaired accommodation.

Metamizole sodium metabolites can change the color of urine to red, which does not have clinical significance.

Drug interaction

Histamine H 1 receptor blockers, butyrophenones, phenothiazines, tricyclic antidepressants, amantadine and quinidine - an increase in m-anticholinergic action is possible.

Chlorpromazine or other phenothiazine derivatives - the development of severe hyperthermia is possible.

Non-narcotic analgesics, tricyclic antidepressants, oral hormonal contraceptives and allopurinol - increase the toxicity of the drug.

Phenylbutazone, barbiturates and other inducers of microsomal enzymes - a decrease in the effectiveness of metamizole sodium.

Sedatives and anxiolytic drugs (tranquilizers) - increased analgesic effect of metamizole sodium.

X-ray contrast drugs, colloidal blood substitutes and penicillin - combinations with drugs containing metamizole sodium should not be used.

Cyclosporin - a decrease in the concentration of cyclosporin in the blood is possible.

Oral hypoglycemic agents, indirect anticoagulants, corticosteroids and indomethacin - metamizole sodium displaces these agents from communication with proteins, as a result of which an increase in the severity of their action is possible.

Tiamazole and cytostatics - an increased risk of developing leukopenia.

Medicines with myelotoxic effect: increased hematotoxic effect of the drug.

Codeine, histamine H 2 receptor blockers, propranolol - increased action of the drug due to slow inactivation of metamizole sodium.

Ethanol - enhancing the effects of ethanol.

Solution for injection is pharmaceutically incompatible with other drugs.

Precautionary measures

With caution and under the supervision of a physician, the drug should be used in patients with impaired liver or kidney function, with a tendency to hypotension, bronchospasm, and also with increased individual sensitivity to NSAIDs or non-narcotic analgesics. Metamizole metabolites can sometimes stain urine red.

With prolonged (more than 1 week) use of the drug, it is necessary to control the picture of peripheral blood and the functional state of the liver.

Active substance

What is included in the spazgan and what is it used for in addition to relieving headaches?
Analgin (metamizole sodium) is a non-steroidal anti-inflammatory drug that has a pronounced analgesic (analgesic) effect, and also reduces body temperature (in case of fever),

Pitophenone hydrochloride is a myotropic antispasmodic, which is characterized by a pronounced relaxing effect, aimed mainly at smooth muscle fibers of internal organs.

Thanks to this effect, it is possible to achieve maximum relaxation of smooth muscles, even in the case of severe involuntary spasm,

Fenpiverinia bromide is a representative of the pharmacological group of M-anticholinergics. The mechanism of action of this drug is the blocking effect on the endings of parasympathetic nerve fibers. It also allows you to reduce the tone of smooth myocytes, only a slightly different mechanism.

Side effect

In therapeutic doses, the drug is usually well tolerated. Allergic reactions are sometimes possible (skin rash, itching, very rarely - anaphylactic shock, urticaria), angioedema. In isolated cases - a burning sensation in the epigastric region, dry mouth, headache.
Perhaps dizziness, decreased blood pressure, tachycardia, cyanosis. With prolonged use - hematopoiesis disorders: thrombocytopenia, leukopenia, agranulocytosis (may manifest as the following symptoms: unmotivated fever, chills, sore throat, difficulty swallowing, stomatitis, as well as the development of vaginitis or proctitis).
With a tendency to bronchospasm, provoking an attack is possible.
Very rarely - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
Rarely (usually with prolonged use or high doses) - impaired renal function: oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red. Very rarely - decreased sweating, paresis of accommodation, difficulty urinating.
Local reactions: with intramuscular administration, infiltrates at the injection site are possible.
All side effects should be reported to your healthcare provider.

Interaction with other drugs

The simultaneous use of Spazgan with other non-narcotic analgesics can lead to a mutual increase in toxic effects. Tricyclic antidepressants, contraceptives for oral administration, allopurinol disrupt the metabolism of metamizole sodium in the liver and increase its toxicity.
Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect of metamizole sodium.
The simultaneous use of cyclosporine reduces the level of the latter in the blood.
Sedatives and tranquilizers enhance the analgesic effect of metamizole sodium.
With simultaneous use with H1-histamine blockers, butyrophenones / phenothiazines, amantadine and quinidine, an increase in M-anticholinergic action is possible.
With simultaneous use with ethanol - mutual enhancement of effects.
Concomitant use with chlorpropromazine or other phenothiazine derivatives can lead to the development of severe hyperthermia.
X-ray contrast drugs and colloidal blood substitutes should not be used during treatment with preparations containing metamizole sodium.
Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin from the plasma protein bond, can increase the severity of their action.
Tiamazole and cytostatics increase the risk of developing leukopenia.
The effect is enhanced by codeine, H2-histamine blockers and propranolol (slows the inactivation of metamizole sodium).
Solution for injection is pharmaceutically incompatible with other drugs.
If necessary, the simultaneous use of these and other drugs should consult a doctor.

Vacation terms and price

The average cost of Spazgan (tablets number 20) in Moscow is 90 rubles. The price of injections of 5 ml is 170 rubles for 5 ampoules. The drug can be purchased at the pharmacy freely, without a prescription.

The expiration date of the drug is indicated on the package. Injection should be stored in a cool, dark place for no more than 2 years.Tablets can be stored at room temperature for 3 years from the date of production.

Main parameters

The composition of Spazgan includes metamizole sodium, fenpiverinium bromide, pitophenone hydrochloride. As auxiliary components, lactose, colloidal silicon dioxide, magnesium stearate are used. The drug is offered in two main forms - traditional tablets for oral use, as well as an injection solution. The medicine can be administered intramuscularly or intravenously in an outpatient setting, a hospital.

The composition of Spazgan includes metamizole sodium, fenpiverinium bromide, pitophenone hydrochloride.

The drug is offered in the form of an injection solution.

If the functioning of the gastrointestinal tract is not impaired, then the patient is prescribed tablets.

The release form is selected by the doctor individually. If the functioning of the gastrointestinal tract is not impaired and sufficient absorption of the components by the intestinal walls is ensured, then the patient is prescribed tablets. If there is a need for a quick effect of the drug on the body, then it is used, bypassing the digestive tract, by injection.

Spazgan is indicated for fighting severe pain. It has several pronounced effects at once:

  • Painkillers
  • Antipyretic,
  • Antispasmodic.

The drug also has a slight anti-inflammatory effect, but it is almost not expressed, therefore, the drug is not used for this purpose. Indications for the use of Spazgan are diverse.

It is used for severe headaches, migraines, pain relief for gallstone disease, inflammation of the kidneys, urinary tract. It is used by girls and women during menstruation in the fight against drawing pain in the lower abdomen.

The drug is often prescribed in the form of injections after surgical interventions during the recovery period. It does not apply to narcotic drugs, so it can be used for a long time and without an appropriate prescription.

Spazgan is allowed to be used in the treatment of children. It well reduces fever.

Spazgan copes with this task very quickly, unlike the more sparing paracetamol or ibuprofen. Often it is not recommended to use it in the treatment of children due to the abundance of contraindications and side effects.

Spazgan is used for severe headaches that occur against a background of a sharp increase in blood pressure. Hypertensive patients often take this drug on an ongoing basis, but it is not recommended to abuse it. Due to the antispasmodic effect, it slightly reduces pressure, but more effective drugs are required to completely eliminate hypertension.

Spazgan composition

India is the developer of Spazgan, but today many pharmacological companies around the world produce this drug. Basically, both in tablets and in Spazgan injections, the composition is identical:

  1. Metamizole sodium (0.5 g) relieves pain, which is the main indication, which helps Spazgan.
  2. Pitophenone hydrochloride (2 mg) is a myotropic antispasmodic that dilates blood vessels, relieves spasms, relaxing muscles and lowering tone.
  3. Cholinoblocker - fenpiverinia bromide, has a mild inhibitory effect on the nervous system, relieving cramping, colic, limiting the functioning of the glands and excretory systems.

However, the main analgesic component of this antispasmodic is metamizole sodium, the same Analgin is prohibited in some countries. Therefore, Indian pharmacologists have released a safer version of this drug - Spazgan neo, in which Analgin is replaced by Ibuprofen. All other components of the updated version of the drug remained unchanged.

Spazgan: instructions for use and why it is needed, price, reviews, analogues

Anesthetic based on three active ingredients.Due to the complex effect on pain and the mechanism of its occurrence, Spazgan has a quick and powerful effect. The drug is inexpensive and dispensed without a prescription, but it is impossible to exceed the doses indicated in the instructions, since an overdose can cause dangerous symptoms.

Dosage form

Spazgan is available in two forms of release - tablets for oral administration and a solution for injection. The tablets are round in white. 10 pieces are packaged in a blister. Cardboard package contains 2 blisters.

The solution for injection is available in ampoules of 5 ml. The package contains 5 or 10 ampoules. Ampoules for injection are often used in a hospital or in acute conditions, when the tablets do not bring the expected and quick effect.

Description and composition

Spazgan is a drug from the group of antispasmodics with an analgesic effect. Refers to combination drugs. It contains sodium metamizole, fenpiverinium bromide, pitophenone hydrochloride, as well as auxiliary substances.

Taking the drug can not only stop the pain, but also have an antipyretic effect. With proper administration of the drug, the active components act in the area of ​​pain, relieve smooth muscle spasms.

The drug can be used in different areas of medicine for pain. Spazgan can be attributed to drugs with a wide spectrum of action.

Its use will help to cope with headaches, intestinal and renal colic, it is also effective for the symptoms of flu, colds, which are accompanied by muscle pain and fever.

1 tablet contains:

  • metamizole sodium - 500 mg,
  • pitophenone hydrochloride - 5 mg,
  • fenpiverinium bromide - 0.1 mg.

1 ml of injection contains:

  • metamizole sodium (analgin) - 500 mg,
  • pitophenone hydrochloride - 2 mg,
  • fenpiverinium bromide - 0.02 mg,
  • water for injections.

Spazgan - ampoules

Pharmacology in addition to the tablet form also produces Spazgan injections. Intravenous and intramuscular injections are available in ampoules and are a clear, yellowish or colorless solution. The composition of this form of antispasmodic is identical to tablets, with the only difference that of the auxiliary components there is only water:

  • water -1 ml
  • Analgin - 0.5 g,
  • fenpiverinia bromine - 0.02 mg,
  • pitophenone hydrochloride - 2 mg.

Pharmacological group

Spazgan is a combined medication that contains three active components, each of which has a specific effect on the cause and symptoms of the pain syndrome.

  • Metamizole is a non-narcotic analgesic that allows you to relax smooth muscles, inhibit prostaglandin synthesis, block acetylcholine m-receptors, reduce fever and inflammation.
  • Pitophenone hydrochloride is a myotropic antispasmodic that has a direct effect on muscle tissue, relieves cramping, and pain.
  • Fenpiverinia bromide is an anticholinergic blocker with analgesic and relaxing effects, accelerates the therapeutic effect of the drug.

In the complex, the components of the drug anesthetize the foci of inflammation, relieve spasms and irritation of nerve endings.

After taking the drug, its active ingredients quickly penetrate the digestive tract, after which they penetrate the blood stream. The effect after taking the drug is observed after 10 to 12 minutes and lasts for 3 to 4 hours. The metabolism of the drug occurs in the liver, excreted in urine, bile, feces.

Dosage and administration

: taken orally 1 tablet after a meal once two times with an interval of 10-12 hours. The daily average therapeutic dose is 2 tablets. The duration of therapy is 5 days.

Solution for injection

: once 2-4 ml. The maximum daily therapeutic dose is 4 ml. Do not mix the solution with other substances!

Intravenous administration: infusion rate - 1 ml per minute, in a horizontal position of the patient, controlling heart rate, blood pressure, respiratory rate.The solution should be heated to 36-37 degrees before administration.

12-24 months - 0.1-0.2 ml - intramuscularly, intravenously,

3-4 years - 0.2-0.3 ml - intravenously, 0.3-0.4 ml - intramuscularly,

5-7 years - 0.3-0.4 ml - intravenously, 0.4-0.5 ml - intramuscularly,

8-12 years old - 0.5-0.6 ml - intravenously, 0.6-0.7 ml - intramuscularly,

12-15 years - 0.8-1.0 ml - intravenously, 0.8-1.0 ml - intramuscularly.

Spazgan is prescribed in tablets to patients with pronounced pain syndrome. Adults are allowed to take 1-2 tablets 3-4 times a day. Between receptions should pass at least 3-4 hours. You can not take more than 8 tablets per day. The drug is prohibited for use in the treatment of children under 8 years of age. From 8 to 12 years old it is allowed to take one tablet 1-3 times a day.

If Spazgan is prescribed in the form of an injection, the method of administration and dosage are determined only by the attending physician. The drug can not be used simultaneously with other means. The age and weight of patients is taken into account when determining the exact single and daily dosage.

With intravenous administration, the drug is dripped slowly, you can not increase the speed of injection more than 1 ml per minute. Before intramuscular injection, the ampoule with the solution is first warmed in the palm of the hand. The daily dose for an adult patient should not exceed 4 ml.

The maximum duration of Spazgan treatment in tablets or injections should not exceed five days. If symptoms persist, a positive therapeutic effect is not achieved, the attending physician must review the selected treatment regimen and prescribe other drugs. The risks of pronounced side effects otherwise increase.

Adults and adolescents over 15 years of age are usually prescribed 1-2 tablets 2-3 times a day. The maximum daily dose is 6 tablets.

Children can be given the drug only as directed by a doctor. Doses depending on age (recommended single / maximum daily allowance):

  • 12-14 years old - 1 tab. / 6 tab. (1.5 tab. 4 times a day),
  • 8-11 years old - 0.5 tab. / 4 tab. (1 tab. 4 times a day),
  • 5-7 years - 0.5 tab. / 2 tab. (0.5 tab. 4 times a day).

The duration of taking Spazgan is no more than 5 days.

An increase in the daily dose or duration of treatment is possible only on the recommendation of a doctor.

Spazgan solution is intended for intramuscular (IM) and intravenous (IV) administration. Before injection, the solution should be warmed in the hand.

For adults and adolescents over 15 years of age with acute severe colic, the drug is administered:

  • Slowly intravenously (at a rate of 1 ml / minute) at a dose of 2 ml. If necessary, after 6-8 hours do a second injection,
  • Intramuscularly at a dose of 2-5 ml 2-3 times a day.

Recommended doses and route of administration of the drug for children:

  • 12-15 years: in / m or in / in 0.8-1 ml,
  • 8-12 years (31-45 kg): in / m at 0.6-0.7 ml or in / at 0.5-0.6 ml,
  • 5-7 years (24-30 kg): oil on 0.4-0.5 ml or iv on 0.3-0.4 ml,
  • 3-4 years (16-23 kg): in / m at 0.3-0.4 ml or in / at 0.2-0.3,
  • 1-2 years (9-15 kg): intramuscularly 0.2-0.3 ml or iv on 0.1-0.2 ml,
  • 3-11 months (5-8 kg): only IM in a dose of 0.1-0.2 ml.

Biliary colic

According to statistics, more than 25% of women worldwide suffer from. In most cases, for the first time, patients learn about the presence of this disease with the appearance of biliary colic. This condition is described as intolerable pain, which is accompanied by several more symptoms. The leading cause is spastic contraction of smooth muscles, developing to block the output section of the gallstone. With a complete violation of the outflow of bile, there is a high probability of the appearance of subhepatic jaundice, manifested in the form of yellowing of the skin, mucous membranes, sclera, itching and general intoxication. Pain attacks are easily stopped by taking antispasmodics. Drugs such as Spazgan provide relaxation to the smooth muscles of the gallbladder, allowing the stone to move further along the bile ducts, enter the intestines and exit with feces.

For adults

The main indication for the use of the drug is:

  • renal colic,
  • intestinal cramps
  • migraine,
  • myalgia
  • neuralgia,
  • joint pain of unclear etiology,
  • dysmenorrhea.

Other pain syndromes affecting the soft tissues of internal organs and systems can also serve as an indication for the appointment of the drug.

The drug found its wide application for pain in women during menstruation, and this tool is often used for spastic pain in the stomach or migraine.

If the nature of the pain syndrome is unknown, it is better to refuse to take pills or Spazgan injections. Their reception can complicate the process of determining the cause when contacting doctors.

Intestinal colic

This condition occurs due to cramping contractions of the smooth muscle structures of the intestine. It manifests itself in the form of abdominal pain, delayed stool and flatulence. There are several pathologies that can cause intestinal colic and for each of them there is a certain treatment algorithm. If intestinal colic arose once, went away on its own and did not cause any complications, then a person does not need specific treatment. If at the end of a painful attack the patient has diarrhea, vomiting, bloating, and stool retention in this case, it is advisable to seek the advice of a doctor. Among the leading causes of this symptom are intestinal obstruction, infection, food poisoning, and unbalanced nutrition. At the emergency stage, it is not recommended to take painkillers, in view of the high probability of “lubricating” the clinical picture. After examining the surgeon and confirming the diagnosis, the doctor may prescribe Spazgan or another antispasmodic to reduce the severity of pain.

For children

Spazgan can be used for children from 5 years. Indications for its use may be elevated body temperature, inflammatory processes, febrile seizures, muscle pain.

Despite the possibility of using the drug in pediatrics, many doctors recommend that you refrain from taking it, citing the risks of side effects.

Spazgan for children is more often replaced with drugs like Ibuprofen or Paracetamol.

Neuralgia

Neuralgia is a condition caused by damage to peripheral nerves. Unlike neuritis, this process does not show any additional symptoms other than pain. Neuralgia is primary and secondary. In the first case, during the examination, it is not possible to find the cause of the pain attacks. In the second, it is possible to fix the presence of pathologies that contribute to damage to the nervous tissue (inflammation, cancer formation, etc.). Localization of pain can be in any part of the body. With a prolonged course, neuralgia turns into neuritis. Most neuralgia is very well stopped with Spazgan.

Localization of pain along the trigeminal nerve

Causes

The causes of severe pain in the head can be many, differing in origin and pathogenetic mechanism. For instance:

  1. Change in atmospheric pressure and irritation of baroreceptors located in the wall of blood vessels supplying the brain with blood,
  2. Stress and nervous strain,
  3. Prolonged insomnia
  4. Menstrual cycle,
  5. A side effect of taking certain drugs.

Given the fact that a headache can occur for various reasons, you need a tool that would act on each of these causes, since it is far from always possible to reliably find out the origin of the headache and the causes of the manifestation of this symptom.

As a result, for the relief of headache, it is considered advisable to use combined preparations, which include several active substances. One of these is spazgan for headaches (the generic drug of the original is spazmalgon, which is slightly cheaper).

Spazgan contraindications

Taking any drug raises a lot of questions regarding contraindications. For what diseases can the use of this drug be limited or canceled? Is Spazgan allowed during pregnancy? Can Spazgan be drunk for children? The instructions for medicines provide comprehensive information on this subject:

It is forbidden to take Spazgan with the following diagnoses:

  • severe pathologies of the liver and kidneys,
  • gastric ulcer and gastrointestinal tract,
  • bowel obstruction,
  • violation of bone marrow hematopoiesis,
  • cardiological disorders
  • glaucoma,
  • prostatic hyperplasia
  • collapse,
  • megacolon
  • erythropathy G-6-FD,
  • individual intolerance to the components of the drug.

Do not use Spazgan during pregnancy and lactation. It is especially dangerous to take this drug in the first and last trimester of pregnancy. Children under 5 years of age should also not be given Spazgan tablets. Intravenous injections are limited only for babies who have not reached the age of three months or with a body weight of less than 5 kg.

Use caution when using Spazgan is necessary for those who have a history of:

  • bronchial asthma,
  • hypotension
  • allergies of various types,
  • intolerance to NSAIDs.

For pregnant and lactating

During pregnancy and breastfeeding, the use of Spazgan in tablets or injections is not recommended. An exception to the use of this drug may be conditions in which taking the medicine does not harm the fetus or the course of pregnancy.

Contraindications

Instructions for use of the drug Spazgan recommends that you familiarize yourself with possible contraindications before using the drug, including:

  • severe kidney disease
  • bowel and stomach obstruction,
  • liver dysfunction
  • children under 5 years old.

Dosage and Administration

Spazgan is recommended to be used only in the acute period of the disease with severe pain. Long-term use of the drug can cause an addictive effect, which will lead to ineffectiveness of the drug.

For adults

Adults are advised to use 1 to 2 tablets 3 times a day for pain relief. Tablets are washed down with a sufficient amount of water. The duration of the drug cannot last more than 5 days.

The injection can be used for intramuscular or intravenous administration. The dose of the drug is calculated individually, but should not exceed 5 ml per 1 injection. The frequency of injections is 1 to 2 per day.

For children

For children, the medicine can be used from 5 years. The recommended dose of the drug is 0.5 tablets 2 times a day. Children from 8 years old can be given 1 tablet of the drug no more than 2 times a day. The duration of the drug is 2 to 5 days.

For pregnant and lactating

Tablets or injection is not used during pregnancy and lactation. Its use increases the risk of abortion in the early stages and premature birth in the late trimester. With lactation, the drug can be used only if, for the period of taking the drug, the baby is transferred to artificial mixtures.

Analogs

Among Spazgan's analogues, one can distinguish preparations by composition (structural) and means by therapeutic effect, that is, those that have a different composition, but are also used to relieve pain:

  • Baralgetas is a non-narcotic analgesic and myotropic antispasmodic. Used to eliminate mild to moderate pain.
  • Metamizole is a derivative of pyrazolone with analgesic, antipyretic and anti-inflammatory effects.
  • Maxigan is a combined type anesthetic that can relieve muscle cramps.
  • Spazmalgon is an antispasmodic for the relief of pain, has an affordable price, and is often used in practice.

The reception of any analogue must be agreed with the doctor.

The cost of Spazgan is an average of 171 rubles. Prices range from 45 to 520 rubles.

Spazgan Headache

Spazgan is one of the most effective drugs for headaches, as it has a quick and lasting antispasmodic effect on smooth muscles and has analgesic properties (anesthetizes).

The three components that make up the drug comprehensively attack the source of pain, quickly relieve vascular spasms, eliminate malaise and lower body temperature.Subject to dosage, the drug is well tolerated by patients. With prolonged use (more than 1 week), the liver should be monitored.

It is not recommended to take Spazgan with other analgesics of non-narcotic origin in order to avoid an increase in toxic effects on the body.

Spazgan during pregnancy

Metamizole sodium, which is part of Spazgan, inhibits the synthesis of prostaglandins, which is involved in many processes in the body and in labor. As a result of its administration, labor activity can weaken, pregnancy overtaking occurs.

In the early stages, the drug can lead to abnormalities in the development of the fetus, nephrotoxic effect (kidney damage), and in the later stages to premature closure of the ductus arteriosus in the child, which causes pulmonary hypertension and heart problems.

Therefore, taking Spazgan is prohibited in the first trimester of pregnancy, in the last 6 weeks of pregnancy, and at other times - only if it is beneficial to the mother in excess of the possible harm to the baby.

Of course, a single dose is unlikely to cause permanent damage to the child and mother, but for prolonged use it is not suitable.

The content of the site: Dmitry N.

Spasgan

Spazgan - combination drug with analgesic and antispasmodic component. Spazgan is a combination of three drugs: metamizole sodium + pitofenone + fenpiverinium bromide, which have a quick and lasting antispasmodic effect with a simultaneous analgesic effect.

  • Metamizole sodium It belongs to the group of non-narcotic analgesics, being a derivative of pyrazolone.
  • The release of prostaglandins in the centers of thermoregulation is inhibited, which increases heat transfer and removes manifestations of fever, while not reducing normal body temperature.

The main effects of the drug are associated with a suppression of the activity of prostaglandin-H-synthetase, which is accompanied by inhibition of the formation of prostaglandins, and a decrease in their effect on sensitivity to bradykinin, which stimulates painful nerve endings, and as a result, mainly painful and moderate inflammatory reactions are stopped.

Pitophenone hydrochloride - myotropic antispasmodic with a directed effect on the layer of smooth muscle fibers of internal organs. The action of pitophenone hydrochloride is manifested by the relaxation of smooth muscles with a pronounced antispasmodic effect.

  1. Fenpiverinia bromide is a representative of the M-anticholinergic group, it has a blocking effect on the endings of parasympathetic nerve fibers, which is accompanied by a decrease in the tone of the smooth muscles of the stomach, gall bladder and ducts, urinary system, reduces intestinal motility, and causes an additional antispasmodic and analgesic effect.
  2. Elimination occurs mainly with urine, a small amount is excreted in the bile.

The combined effect of the drug is manifested in the form of synergism of medicinal substances, and is expressed by the mutual strengthening of their pharmacological action. The primary pharmacological effect of the drug occurs 20-40 minutes after oral administration, the maximum effect is observed after 120 minutes.

  • - pain manifestations accompanied by a spastic state of the smooth muscle layer of the internal organs, - symptomatic therapy for neuralgia, myalgia, ischalgia, arthritis and bursitis, - for hyperthermia as a symptomatic remedy, - headache, with migraine-like manifestations, - functional or organic dysmenorrhea,
  • - biliary dyskinesia.

Tablets: taken orally 1 tablet after a meal once two times with an interval of 10-12 hours. The daily average therapeutic dose is 2 tablets. The duration of therapy is 5 days. Solution for injection: once 2-4 ml. The maximum daily therapeutic dose is 4 ml.

Do not mix the solution with other substances!

Intravenous administration: infusion rate - 1 ml per minute, in a horizontal position of the patient, controlling heart rate, blood pressure, respiratory rate. The solution should be heated to 36-37 degrees before administration.

Parenteral administration in children is permissible according to the strict indications of a specialist: - 12-24 months - 0.1-0.2 ml - intramuscularly, intravenously, - 3-4 years - 0.2-0.3 ml - intravenously, 0.3-0, 4 ml - intramuscularly, - 5-7 years - 0.3-0.4 ml - intravenously, 0.4-0.5 ml - intramuscularly, - 8-12 years - 0.5-0.6 ml - intravenously, 0.6- 0.7 ml - intramuscularly,

- 12-15 years old - 0.8-1.0ml - intravenously, 0.8-1.0ml - intramuscularly.

Allergic reactions: urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), angioedema, in rare cases, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), bronchospastic syndrome, anaphylactic shock.

From the urinary system: impaired renal function, oliguria, anuria, proteinuria, interstitial nephritis, staining of urine in red.From the cardiovascular system: decrease in blood pressure.

From the hematopoietic system: thrombocytopenia, leukopenia, agranulocytosis (may include the following symptoms: unmotivated fever, chills, sore throat, difficulty swallowing, stomatitis, as well as the development of vaginitis or proctitis).

Anticholinergic effects: dry mouth, decreased sweating, paresis of accommodation, tachycardia, difficulty urinating.Local reactions: with i / m administration, infiltrates at the injection site are possible.

- hypersensitivity (including

to pyrazolone derivatives), - inhibition of bone marrow hematopoiesis, - severe hepatic and / or renal failure, - glucose-6-phosphate dehydrogenase deficiency, - tachyarrhythmias, severe angina pectoris, - decompensated chronic heart failure, - angle-closure glaucoma, - prostatic hyperplasia manifestations), - intestinal obstruction, - megacolon, collapse, - pregnancy (especially in the first trimester and in the last 6 weeks),

For iv administration - infant age (up to 3 months) or body weight less than 5 kg. For tablets - children's age (up to 5 years).Carefully: renal / liver failure, bronchial asthma, tendency to hypotension, hypersensitivity to NSAIDs, urticaria or acute rhinitis, provoked by the use of acetylsalicylic acid or other NSAIDs.

During treatment with the drug, it is not recommended to take ethanol. For prolonged (more than a week) treatment, monitoring of the peripheral blood picture and the functional state of the liver is necessary. If you suspect agranulocytosis or in the presence of thrombocytopenia, you must stop taking the drug.

It is unacceptable to use acute abdominal pain for relief (until the cause is clarified). Intolerance is very rare, but the risk of anaphylactic shock after intravenous administration of the drug is relatively higher than after taking the drug inside.

Patients with atopic bronchial asthma and pollinosis have an increased risk of allergic reactions.

Parenteral administration should be used. only in cases where oral administration is not possible (or absorption from the gastrointestinal tract is impaired). Particular care is required when introducing more than 2 ml of solution (risk of a sharp decrease in blood pressure). Intravenous injection should be carried out slowly, in the prone position and under the control of blood pressure, heart rate and BH.

When treating children under 5 years old and patients receiving cytostatics, metamizole sodium should be administered only under medical supervision.

    For i / m administration you must use a long needle.

Influence on the ability to drive vehicles and control mechanismsDuring treatment, caution should be exercised by drivers of vehicles and persons engaged in potentially hazardous activities that require quick physical and mental reactions.

It is possible to stain urine in red due to the release of the metabolite (it does not have clinical significance).
Interaction with other drugs

Injection pharmaceutically incompatible with other drugs.

When combined with histamine and H1-blockers, butyrophenones, phenothiazines, tricyclic antidepressants, amantadine and quinidine, an increase in m-anticholinergic action is possible. It enhances the effects of ethanol, simultaneous use with chlorpromazine, etc.

phenothiazine derivatives can lead to severe hyperthermia. Tricyclic antidepressants, oral contraceptives and allopurinol increase the toxicity of the drug.

Phenylbutazone, barbiturates, and other inducers of hepatic enzymes while concomitantly decreasing the effectiveness of metamizole sodium.

Sedative and anxiolytic drugs (tranquilizers) enhance analgesic effect metamizole sodium.

X-ray contrast drugs, colloidal blood substitutes and penicillin should not be used during treatment with drugs containing metamizole sodium. With the simultaneous administration of cyclosporine, the concentration of the latter in the blood decreases.

Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin, can increase the severity of their action.

Tiamazole and cytostatics increase the risk of leukopenia.

The effect is enhanced by codeine, H2-histamine receptor blockers and propranolol (slows the inactivation of metamizole sodium).

Contraindicated during pregnancy (especially in the first trimester and in the last 6 weeks). Use in nursing mothers requires termination of breastfeeding.

With an overdose of the drug, signs of intoxication of metamizole in combination with cholinolytic manifestations are noted. The most common toxic-allergic syndrome and the phenomena of vascular shock, signs of agranulocytosis, brain damage and gastrointestinal disturbances are somewhat less common.

Symptoms: acute painful attacks in the abdomen, vomiting, drowsiness, confusion, persistent decrease in blood pressure, difficult to correct, signs of severe allergic reactions up to anaphylactic shock, impaired functional state of the liver, kidneys, convulsive manifestations.

Treatment: drug withdrawal, gastric lavage, sorbent intake, use of forced diuresis and hemodialysis. Symptomatic Therapy There is no specific antidote.

  • Spazgan tablets in blisters No. 10 10 tablets in a lightproof blister, 1, 2, 10 blisters in a cardboard box.
  • Solution for injection Spazgan in ampoules 5.0 ml No. 5

5 brown glass ampoules in contour plastic packaging (pallet), 1 or 5 plastic packs in a cardboard bundle.

It is stored in the original packaging. In a dry, dark place at a temperature of no higher than 25 ° C.

  1. 1 tablet Spazgan contains: - active ingredients: metamizole sodium (analgin) - 500 mg, itofenone hydrochloride - 5 mg, fenpiverinium bromide - 0.1 mg,
  2. - excipients: lactose, magnesium stearic acid, colloidal silicon dioxide.
  3. In 1 ml of Spazgan solution contains: - active ingredients: metamizole sodium (analgin) - 500 mg, itofenone hydrochloride - 2 mg, fenpiverinium bromide - 0.02 mg,
  4. - excipients: water - 1.0 ml.

I also carry a spazgan with me, because sometimes I really helped out with a severe headache. I also treat my colleagues with pills if something happens)) And of course this is an indispensable tool for menstruation. Sometimes it happens that the bottom of the stomach twists so that you just do not want to live. Very painful, muscle spasm unreal. And it is spazgan that saves in these cases! Good antispasmodic

I always have spazgan in my purse, because it helps very well with headaches, relieves spasm, so I cannot imagine my life without these pills. I also save him at the beginning of menstruation, when the pain begins to intensify, the stomach pulls and hurts, I take a pill and after half an hour everything goes away