Which is better: Capoten or Captopril?

Kapoten is a widely used antihypertensive drug. The medicine is prescribed for the treatment of conditions associated with an increase in blood pressure in humans. If for some reason the use of the drug becomes impossible, Kapoten analogues are selected for the patient. In the article, we consider the main effect of a drug, its popular substitutes and reviews about them.

What is Kapoten used for?

Kapoten belongs to the group of ACE inhibitors, is prescribed to patients with the following conditions:

  • arterial hypertension of various origins,
  • chronic heart failure or acute period after myocardial infarction,
  • pathological changes in the left ventricle of the heart, including the latent course,
  • jumps in blood pressure on the background of diabetic nephropathy.

The drug is produced in the form of tablets, which include such an active substance as captopril. Tablets are packaged in blisters. A cardboard pack contains 2 or 4 plates of 10-14 tablets each.

The pharmacological effect of the drug is ensured by inhibition of the transition of the enzyme angiotensin I to angiotensin II. This ensures the expansion of blood vessels, lowering blood pressure in them. The blood circulation of the brain is not disturbed, pre- and afterload from the heart muscle are reduced, and renal and coronary blood flow is restored.

Kapoten is taken orally, washed down with plenty of water. The drug is rapidly absorbed, the hypotensive effect occurs after 30-40 minutes. The maximum amount of active substance in the body is noted after 90 minutes. The elimination half-life is 3-4 hours. It is excreted mainly by the kidneys.

How to replace the medicine

The list of analogues of the drug is quite large. The modern pharmaceutical market offers a wide range of Kapoten substitutes. Some of them are cheaper, others are more expensive. Each remedy has its own contraindications, side effects, so the answer to the question of how to replace Kapoten should be exclusively specialist, based on the patient’s diagnosis, history and individual characteristics of the body. We suggest considering a list of drugs that are similar in their effect, composition and scope.

Important! The article provides familiarization information. For more accurate information, contact your doctor.

The product is in the form of light orange flat tablets with beveled edges. Sometimes white blotches are allowed. The active substance of the drug is enalapril maleate. Enap is an angiotensin-converting enzyme inhibitor drug.
It is known that the renin-angiotensin system plays an important role in the regulation of human blood pressure. It is she who is responsible for the circulation and volume of blood in the body. Enap has an overwhelming effect on it, due to which there is an expansion of medium and large vessels, blood pressure decreases.

  • primary hypertension
  • complex treatment of heart failure,
  • prevention of complications, including myocardial infarction, in patients with impaired left heart ventricle.

The amount of funds taken at the initial stage of treatment is usually 5 mg. In the absence of the desired therapeutic effect, the rate is slowly increased over two weeks.

  • intolerance to other drugs belonging to the group of ACE inhibitors,
  • pregnancy,
  • history of Quincke's edema during treatment with angiotensin-converting enzyme inhibitors,
  • pathological processes in the kidneys and liver.

From pharmacies, the drug is dispensed by providing a prescription to the attending physician.Self-treatment with its help is strictly contraindicated.

Andipal

Andipal is a multicomponent drug that includes papaverine, dibazole, analgin and phenobarbital. The substitute has a mild analgesic, sedative, antispasmodic effect.

Indications for use:

  • cerebral spasms in the brain,
  • migraine,
  • arterial hypertension,
  • circulatory disturbance.

The dosage of the drug is determined by the doctor, taking into account the diagnosis. Typically, patients are prescribed 2-3 tablets throughout the day, washed down with water.

  • muscle weakness, cramps,
  • impaired glucose in the body,
  • various skin pathologies,
  • acute liver, kidney dysfunction.

Among the side effects can be identified digestive disorders, nausea, pain in the stomach and intestines, drowsiness, depression, changes in blood composition.

Moxonidine

Moxonidine refers to antihypertensive drugs that provide reflex and tonic control of the sympathetic nervous system. The tool reduces blood pressure, while the frequency of heart beats and blood circulation in the brain is not disturbed.

The main indication for use is arterial hypertension of various origins, including increased pressure against the background of diabetic nephropathy and other diseases.

  • failure of the patient to be 18 years old,
  • pregnancy,
  • a history of epileptic seizures,
  • severe heart failure
  • bradycardia and acute arrhythmia,
  • heart failure in the acute period.

Side effects include allergic manifestations (skin itching, rashes, nasal congestion), fatigue, depression, headache, dry mouth and other negative conditions.

Instructions for use of the drug indicate that treatment of patients should begin with a dosage of 20 mg throughout the day. Gradually, the norm increases, but cannot exceed 60 mg.

Enalapril

Another popular drug belonging to the group of ACE inhibitors is Enalapril. The drug is produced by the Russian company NIZHFARM AO in the form of round biconvex tablets. The active component of the described drug is enalapril maleate.

Enalapril has an effect on the rate of conversion of the hormone angiotensin I to angiotensin II, so that blood pressure returns to normal. The action of the drug is aimed at restoring renal and coronary blood flow, reducing pre- and afterload from the myocardium, increasing the tolerance of the cardiovascular system to physical and psychological stress.

  • Renovascular primary hypertension
  • prevention of myocardial infarction, coronary ischemia and other complications in patients with impaired activity of the left ventricle of the heart,
  • unstable angina pectoris.

The initial dosage of the drug is usually from 2.5 mg. The dose increases once every 7 days, can not exceed more than 60-80 mg, depending on the condition of the patient.

  • narrowing of the renal arteries of a unilateral or bilateral type,
  • Quincke's edema in the medical history,
  • intolerance to enalapril and other drugs of this group,
  • pregnancy,
  • failure to reach 18 years.

Physiotens

Physiotens includes an active substance such as moxonidine. The product is in the form of pink round film-coated tablets. The drug has a hypotensive effect, affecting the links of the system responsible for the regulation of blood pressure.

The initial dosage is usually from 20 mg per day. In especially difficult situations, the doctor may prescribe up to 40 mg. To determine the exact amount of medication needed for a particular patient, the doctor must monitor the body's response to the administered therapeutic dose.

  • migraine,
  • extremely rarely diagnosed with loss of consciousness,
  • a strong decrease in blood pressure,
  • skin rashes,
  • apathy, fatigue,
  • sleep disturbance,
  • muscle pain, cramps.

Captopril

Many patients are faced with the question, which is better, Capoten or Captopril? This question cannot be answered unequivocally, because both of these drugs include the same active substance and have the same therapeutic effect. The therapeutic effect of both drugs depends on the disease and individual tolerance of funds by the body.

Captopril is used in such conditions:

  • arterial hypertension, provoked by diseases of the heart and blood vessels, as well as diabetic nephropathy,
  • complex treatment of heart failure, including to prevent heart attacks and other complications.

The specialist selects the dosage for each patient separately, based on clinical indications and the diagnosis.

More often, the initial dose of the drug is from 6.25 mg, gradually increasing. A patient cannot be prescribed more than 150 mg of the drug per day.

Among the contraindications are intolerance to Captopril and other drugs of this group, age up to 18 years, pathology of the kidneys and liver, pregnancy, low blood pressure, narrowing of the mouth of the aorta, cardiogenic shock.

Patient Reviews

Love, Moscow
“If arterial hypertension is not treated in a timely manner, it will not lead to anything good. Itself has been suffering from high blood pressure for over 10 years. During the increase, I feel very bad, my head hurts, I feel chest tightness and pain. Enap medicine is saving me. The doctor prescribed me pills after an examination in a hospital. I’m very pleased with the product. ”

Ivan, Khabarovsk
“I got to the hospital six months ago with a heart attack. Prior to this, he did not monitor his health, and explained headaches and weakness by constant fatigue. Through bitter experience, he was convinced that his pressure should be monitored. Now, to normalize his level, I use Enalapril. The doctor said to regularly measure blood pressure, if necessary, take a pill. Fortunately, I feel good now. ”

Alina, Barnaul
“With pressure surges, I take Andipal. My grandmother also used pills. Now I am faced with the problem of high blood pressure. In addition to taking medication, I try to lead a healthy lifestyle, eat right. I hope I don’t have any complications. ”

Catherine, Magnitogorsk
“Previously, cores and elderly patients suffered from increased pressure, but now this scourge torments even many young people. I have the most rapid heartbeat and increased pressure regularly occurs due to stress. The doctor prescribed Captopril to me. One pill and my condition is improving. I’m planning to change the medicine soon, so I’ll have to start looking for a suitable analogue. ”

Main differences

Analyzing the composition and abilities of capoten and captopril, doctors conclude that they have the same indications and side effects. Both help reduce pressure when there is a sharp jump in performance.

A small difference is only in the fillers, and on this occasion, opinions were divided:

  1. The presence of auxiliary agents does not affect absorption or effectiveness, it depends more on the manufacturing technology and formula.
  2. Kapoten supplements make the drug more effective because they reduce the risk of adverse reactions. The same cellulose accelerates the dissolution and absorption of the drug.

The second difference that determines the interest of hypertensive patients is the price difference.

  1. Kapoten. A package of 40 tablets costs 200-270 rubles.
  2. Captopril. A package of 40 tablets costs from 12 to 60 rubles.

This is due to the commercial rules for the sale of drugs, kapoten is a patented drug. More often, patients buy a cheaper option, believing that if the effect is the same, then you should not overpay.

Contraindications

If we consider contraindications, then they are almost identical.

  • pregnancy,
  • breast-feeding,
  • age to 18 years
  • intolerance to the components of the drug,
  • transferred angioneurotic edema,
  • impaired kidney or liver function,
  • hyperkalemia
  • renal artery stenosis,
  • artery stenosis of one kidney,
  • condition after a kidney transplant,
  • stenosis of the mouth of the aorta.

Captopril still has cardiogenic shock, and capoten, taking into account excipients, lactose intolerance, glucose-galactose malabsorption syndrome and lactase deficiency.

With extreme caution, both drugs are used for:

  • severe autoimmune diseases of the connective tissue,
  • poor bone marrow hematopoiesis,
  • diabetes
  • coronary heart disease
  • vomiting, diarrhea,
  • on hemodialysis
  • after operation,
  • a sodium-restricted diet
  • use with diuretics, potassium preparations, immunosuppressants, lithium preparations.

How does the drug work?

Hypertension is an ailment in which blood pressure indicators exceed the mark of 150/100 mm Hg. Normally, this indicator should be 120 by 80 mmHg. Art. There are 3 degrees of severity of hypertension.

With 1 severity, Andipal is allowed. What is the principle of action of the medication? To answer this question, you need to analyze the composition of the tablets in more detail. The active components of the medication are:

  1. Metamizole sodium (analgin). The component allows you to eliminate pain of various localization and genesis, reduce body temperature. The substance has a high absorption. When absorbed, metamizole sodium increases the sensitivity threshold of pain centers in the hypothalamus.
  2. Bendazole The substance is an antispasmodic. Bendazole helps to dilate blood vessels, stabilize the spinal cord, restore nerve endings on the periphery.
  3. Papaverine hydrochloride. The component is an antispasmodic. Papaverine promotes vasodilation, a decrease in the level of calcium in the cells, and a decrease in the general tone of the smooth muscle structure of the surface of internal organs. Due to this therapeutic effect, when using tablets, it is possible to stabilize blood pressure and improve blood circulation.
  4. Phenobarbital. The substance has sedative (sedative) properties. It helps to enhance the effects of other active components of Andipal.

The composition of the tablets also includes auxiliary components, namely talc, potato starch, calcium stearate, stearic acid.

Instructions for use of the drug

Now I need to say a few words about high blood pressure. It is immediately worth noting that Andipal can not be used if intraocular or intracranial pressure rises. The use of the drug is justified only with arterial hypertension. Doctors recommend taking pills in cases where blood pressure exceeds 140-160 (upper threshold) / 100-120 (lower threshold) mmHg. If the indicators exceed the mark of 170 by 130 mmHg, then it is necessary to use more effective drugs - ACE inhibitors, calcium antagonists, sartans, diuretics.

With what they help and at what pressure the Andipal tablets will be effective, everything is extremely clear. Now you need to indicate the dosage. The instructions say that it is enough to take 1-2 tablets 2-3 times a day. The duration of therapy usually does not exceed 7-10 days.

Before using the medication, it is advisable to consult with your doctor, as dose and duration adjustments may be necessary.

Contraindications and side effects

The list of contraindications also includes a deficiency of glucose-6-phosphate dehydrogenase, blood diseases, porphyria, tachyarrhythmia, angina pectoris, acute intestinal obstruction, severe impairment of the kidneys and liver. It is strictly forbidden to take pills for children under 8 years of age. Pregnant and lactating women are also better off refraining from taking the medicine.

Possible side effects:

  • Constipation, nausea, abdominal pain.
  • Allergic reactions, including conjunctivitis, urticaria, Quincke edema.
  • Nephritis.
  • Redness of urine.
  • Drowsiness.
  • Headache.
  • Increased sweating.
  • With prolonged use, leukopenia, thrombocytopenia and agranulocytosis may develop.

With an overdose, anaphylactic reactions may develop. A sharp drop in blood pressure (hypotension) is also not ruled out.

Reviews and analogues

There are also negative comments. Some hypertensive patients were unhappy with the result due to the fact that when using the tablets they were disturbed by digestive disorders and severe headaches.

Andipal has no identical substitutes in composition. But as an alternative, you can use:

  1. For relief of headache with high blood pressure - Aspirin, Analgin, Drotaverin.
  2. To normalize blood pressure, you can take Papazol, Nebivolol, Bisoprolol (both imported and domestic), Metoprolol, Nebivolol.

Some synthetic products are quite harmful and often cause side effects. Therefore, to stabilize blood pressure, you can use effective dietary supplements. For the treatment of hypertension in adults and elderly patients, Normalife is perfect.

The medication helps to “equalize” blood pressure, improve blood circulation and reduce the likelihood of complications of hypertension progressing (stroke, heart attack, heart failure). The drug is not able to do harm, and is completely safe for the body. The efficacy of Normalife has been proven during medical trials in China, the USA and EU countries.

Doctors reviews

What can I say about the drug? Of course, it is effective. But I recommend using it only with a severity degree of arterial hypertension. In severe cases, you need to take more effective drugs, that is, ACE inhibitors, beta-blockers, calcium channel blockers, sartans, diuretics. Sometimes I prescribe a combination of several antihypertensive drugs to patients.

To stabilize the pressure, it is enough to take 3-6 tablets of Andipal (daily dosage is indicated). It is advisable to divide the entire daily dose into 2-3 doses. How many days to take Andipal - my patients are often interested.

I highly recommend not taking pills for longer than 10 days, as the likelihood of side effects will increase. Hypertensive patients can only take ACE inhibitors, beta-blockers and sartans for a long time.

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What are the drugs?

By the nature of the action, "Andipal" refers to antispasmodics, vasodilating. It is intended solely to lower the pressure that has arisen due to stress or vascular spasm. It is not suitable to stabilize blood pressure in case of essential hypertension, as if the patient has low blood pressure. The composition of Andipal includes:

  • analgin - suppresses pain, relieves swelling,
  • dibazole - lowers blood pressure,
  • phenobarbital - acts as a sedative,
  • papaverine - relaxes smooth muscles.

Captopril is a drug that reduces blood pressure and peripheral vascular resistance. Stronger effect in combination with nitrates. May be prescribed to newborns and patients with diabetes. It is worth paying attention to taking the medicine by people of advanced age, because an individual dosage is required. Alcohol compatibility is not allowed.

Kaptopren analogs: comparative characteristics and analogues of the latest generation

The pharmaceutical market has a huge amount of drugs to reduce blood pressure. One of them is Kapoten. Given the high cost of the drug, some patients select an analogue.

Regarding the feasibility of such a step, it is recommended to consult a doctor, because substitutes are not always effective.

It is necessary to understand the features of their action, as well as contraindications.

Enap as a substitute

Stage has another active substance - enalapril maleate. He has the same effect as the described drug. The stage shows the result in heart failure of any severity.

Enap has fewer contraindications. It is allowed to appoint even children.

The adverse reactions with the use of Enap are much less than that of Captopril. The use of Enap can cause hypotension, fatigue, headache. Laboratory tests show an increase in the number of transaminases, creatinine, urea, a decrease in the concentration of red blood cells and white blood cells. Patients note nausea, vomiting is possible.

Captopril is more difficult to tolerate and can cause tachycardia, angina pectoris, and even lead to cardiac arrest. Much more adverse reactions are manifested by the digestive tract. In addition to those described above, there is a risk of peptic ulcer, jaundice, pancreatitis. Cases of necrotizing hepatitis have also been reported. Of neurological disorders, doctors note ataxia, loss of consciousness, stroke.

Given these characteristics, Enap is definitely better among other analogues.

Nifedipine and Kapoten: comparative characteristics

Medicines have a different composition, but are similar in effect. Both medicines should be taken before meals twice a day. Nifedipine is not prescribed for patients with severe heart failure and acute myocardial infarction. The use of the drug is allowed no earlier than 4 weeks after a heart attack, but subject to stabilization of the coronary circulation. Kapoten is recommended to be given immediately after an attack, or 3 days after it.

The drug is contraindicated in aortic stenosis, unstable angina, inflammatory processes in the intestine. It is forbidden to combine it with magnesium sulfate. In the treatment of Rifampicin, the dosage of Nifedipine is recommended to be increased. Reduce it to patients who use erythromycin, itraconazole, ritonavir, cyclosporine, cimetidine.

Important! Nifedipine is discontinued gradually, especially if the patient has taken high doses of the drug.

When treating Kapoten, caution should be exercised by patients using antidiabetic agents, diuretics and NSAIDs. Do not combine the product with lithium.

If you compare Nifedipine and Kapoten, the first medicine gives more adverse reactions.

Prestarium as an analogue

The hypotensive effect of Prestarium is provided by perindopril arginine. In medical practice, the medicine is used at any stage of arterial hypertension. The medicine acts quickly, and reaches its maximum concentration in an hour after administration.

The absorption of perindopril, like captopril, decreases with food intake. Therefore, both drugs should be drunk before meals.

The advantage of Prestarium as an analogue is the quick recovery of the patient. Cardiac activity normalizes after a month. In this case, the medicine, unlike captopril-based medicines, is drunk once a day.

List of cheap analogues

Cheap Kapoten analogues can contain many additional ingredients, making them more likely to have negative reactions.

Enalapril is a cheap analogue. Of the contraindications to the medication, allergies, angioedema, impaired renal function and diabetes mellitus are indicated. Side effects while taking the drug are rare, drug withdrawal is not required.

List of analogues of the latest generation

Kapoten and its analogues improve the activity of the cardiovascular system. The list of substitutes includes drugs with the content of captopril in different dosages: 25 and 50 ml.

From the analogues of the latest generation, we can distinguish:

Any of these drugs should be used in a minimum dosage. They can be consumed even with minor kidney damage.

Modern medicines, similar in composition or action, do not adversely affect the nervous system and do not affect potency.

Features of the drug Kapoten

The Russian product is manufactured by Akrikhin. The active ingredient in the composition - captopril, belongs to the pharmacological group of angiotensin-converting enzyme inhibitors. As auxiliary substances, lactose, starch, stearic acid are added. Available in the form of square tablets, each contains 25 mg of the active ingredient. In the package 2 or 4 blisters for 10 or 14 tablets. The cost of a pack of 40 pieces is from 200 to 300 rubles.

The mechanism of action of the substance is based on the suppression of the renin-angiotensin-aldosterone system. The conversion of angiotensin I to angiotensin II is slowed down, which has a vasodilating effect and relieves vascular spasm of arteries and veins. Pressure reduction occurs by increasing renin secretion and lowering the concentration of aldosterone. By reducing the breakdown of bradykinin, its content in the tissues of the body increases.

The accumulation of the peptide has an antianginal effect - it dilates peripheral vessels. Due to the decrease in peripheral vascular resistance, it increases the volume of circulating blood, reduces the load on the myocardium and its oxygen demand. A pronounced antihypertensive effect is achieved within an hour after administration, depending on the initial dosage.

Side effects

  1. Dyspeptic disorders: nausea, diarrhea, abdominal pain, taste disorder, gastritis.
  2. Cardiovascular pathologies: rhythm and conduction disturbances, orthostatic collapse, Raynaud's syndrome.
  3. From the side of the central nervous system: dizziness, changes in sleep quality, decreased performance.
  4. Respiratory manifestations: dry cough, shortness of breath.
  5. Dermatological disorders: rash, skin itching, alopecia.
  6. From the excretory system: dysuric disorders, decreased filtration capacity of the kidneys.

Use with caution with potassium-sparing diuretics, antidepressants, NSAIDs, lithium preparations. Favorable drug interactions with other antihypertensive drugs: beta-blockers, calcium channel antagonists.

Adverse Events

  1. Cardiovascular disorders: arrhythmias, palpitations, flushing.
  2. From the gastrointestinal tract: gastralgia, nausea, vomiting, diarrhea, bloating.
  3. Skin pathologies: alopecia, pruritus, exanthema.
  4. On the part of the respiratory system: shortness of breath, dry unproductive cough.
  5. Nerve pathologies: headache, dizziness, insomnia.
  6. From the genitourinary system: frequent urination, a decrease in the amount of urine.

Before use, a thorough diagnosis of blood, urine, functional examination of the kidneys is necessary

Kapoten and Captopril Sandoz consist of the same active component, have a similar mechanism of action, and have a hypotensive effect. The cost of Kapoten is slightly higher.

Adverse reactions

  1. CNS disorders: dizziness, headache, drowsiness, depression, neurosis.
  2. From the side of cardiovascular pathologies: cardialgia, arrhythmias, orthostatic collapse.
  3. Digestive tract disorders: taste change, nausea, vomiting, constipation, diarrhea, hepatitis.
  4. Respiratory disorders: dry cough, shortness of breath, bronchospasm.
  5. Renal pathologies: urodynamic disorder, renal failure.
  6. Dermatological manifestations: rash, urticaria, skin itching.

Kapoten and enalapril are composed of different substances that belong to the same group of drugs and have a similar pharmacological effect, have the same indications and contraindications. Enalapril has a cheaper cost.

Expensive Tenzotran long-acting

The country of manufacture of the drug is Iceland, the company Actavis Group. The active ingredient in the composition is moxonidine, a selective agonist of imidazoline receptors.Also added are lactose, povidone, titanium oxide, macrogol, magnesium stearate. Release form - round tablets of different colors, film-coated. Each tablet contains 0.2, 0.3 or 0.4 mg of the active ingredient. Available in blisters of 14 pieces, a pack consists of 1 or 2 blisters. The cost of Tenzotran in pharmacies is from 300 to 400 rubles for 14 tablets.

The substance has a central effect, selectively binds imidazoline receptors. It has a tonic effect on the sympathetic nervous system through the tone of pre- and postsynaptic alpha-adrenergic receptors. It is able to increase insulin sensitivity, the production of growth hormone.

The antihypertensive effect is to reduce systolic and diastolic blood pressure due to relaxation of the vascular walls. Reduces the degree of vascular resistance, the content of catecholamines, renin, angiotensin. Reduces the degree of myocardial hypertrophy, angiopathy, fibrosis of the heart muscle.

How do drugs work?

In the composition of Kapoten and Captopril, the main active ingredient is captopril, so that their medicinal properties are similar.

In the composition of Kapoten and Captopril, captopril is the main active ingredient, so that their medicinal properties are similar.

Similarity

The first similarity between Captopril and Kapoten is that they both belong to the same group of medicines - ACE inhibitors.

Indications for use of these drugs are as follows:

  • arterial hypertension,
  • cardiovascular failure
  • renal failure
  • diabetic nephropathy,
  • myocardial infarction
  • renal hypertension,
  • dysfunction of the left ventricle of the heart.

The dosage regimen for hypertensive crisis is one and the same. It is supposed to take medicine one hour before a meal. It is forbidden to grind tablets, only swallow whole with a glass of water. The dosage is prescribed by the doctor individually for each, given the form of the disease, its severity, the general condition of the patient. The maximum daily dose is 25 g. During therapy, it can be increased by 2 times.

If necessary, drugs can be combined with cardiac glycosides, diuretics, sedatives.

But it is not always allowed to use such medicines. Kapoten and Captopril also have the same contraindications:

  • pathology of the kidneys and liver,
  • low blood pressure
  • weakened immunity
  • individual poor tolerance of the drug or its components,
  • pregnancy and breastfeeding.

Children under 16 years of age are also not prescribed such medications.

What is the difference

Captopril and Kapoten are almost identical in composition. But the main difference is the auxiliary compounds. Kapoten contains corn starch, stearic acid, microcrystalline cellulose, lactose. Captopril has more auxiliary components: potato starch, magnesium stearate, polyvinylpyrrolidone, lactose, talc, microcrystalline cellulose.

Kapoten has a more gentle effect on the body than Captopril. But both drugs are potent, so they can not be taken uncontrollably. As for the side effects, Captopril may have the following:

  • headaches and dizziness,
  • fast fatiguability,
  • increased heart rate
  • impaired appetite, abdominal pain, defecation disorders,
  • dry cough,
  • anemia,
  • skin rash.

Kapoten can cause these side effects:

  • drowsiness,
  • dizziness,
  • increased heart rate
  • swelling of the face, legs and arms,
  • numbness of the tongue, taste problems,
  • drying of the mucous membranes of the throat, eyes, nose,
  • anemia.

As soon as side effects appear, you should immediately stop using the drugs and go to the hospital.

Which is cheaper

The price of Kapoten is more expensive. For a package of 40 tablets with a concentration of the main component of 25 mg, the cost is 210-270 rubles in Russia.The same box of captopril tablets will cost about 60 rubles.

For people who have to constantly use ACE inhibitors, this difference is significant. At the same time, cardiologists often recommend Kapoten, indicating that his therapeutic effect is stronger.

Kapoten - analogues

Problems with high blood pressure, unfortunately, are not so rare. Most often, pressure torments older and middle-aged people, but sometimes young people also have to escape from an ailment. Kapoten and its analogues will help to cope with attacks of hypertension and will contribute to their prevention in the future.

What is Kapoten for?

This medication has established itself as an excellent ACE inhibitor. Thanks to Kapoten, the formation of the substance of angiotensin II, which has a vasoconstrictor effect, is stopped. And due to this, accordingly, the pressure normalizes.

The main active ingredient in Kapoten is captopril. In pharmacies today you can find tablets containing 25 or 50 milligrams of this substance. The dosage is selected depending on the problem and the general state of health of the patient. And only a specialist should do this.

Kapoten boasts a fairly large number of advantages:

  1. The medicine significantly reduces the mortality rate from diseases of the cardiovascular system.
  2. The drugs act very effectively and at the same time quite accurately. Kapoten and generic drugs do not affect the nervous system. And men can take medications without worrying about a decrease in potency.
  3. And Kapoten, and its analogues favorably affect the health of the kidneys, slowing down the destructive processes in them. Often, the drug is prescribed even with nephropathy of diabetic origin.
  4. A huge plus of Kapoten and most of its analogues is accessibility.

How can I replace Kapoten?

Despite the many advantages of Kapoten, the tool is not for everyone. Often, patients suffering from hypertension have to look for alternative medicines. Fortunately, Kapoten's substitutes in pharmacies today are presented in a rather wide assortment.

The most famous analogues look like this:

  • Captopril
  • Vero-Captopril,
  • Alkadil
  • Epistron
  • Catopil,
  • Blockordil
  • Angiopril-25,
  • Trandorapril,
  • Monopril
  • Vazolapril,
  • Gopten,
  • Lisinopril and others.

Quite often, patients ask at Kapoten or Anaprilin pharmacies, considering the latter a generic. This is not entirely true. Indeed, drugs produce a similar effect - reduce pressure.

Nevertheless, Kapoten is considered to be more narrowly targeted, while Anaprilin is recommended to be taken in cases where high blood pressure is accompanied by severe tachycardia or trembling, with cardiac ischemia, heart attack and even migraine attacks.

The most popular analogue of Kapoten is Captopril. These drugs are similar not only in their effect, but also in the main active ingredient. Simply put, they differ only in the manufacturing company. But as practice has shown, it also happens that for patients who are not suitable for Kapoten, Captopril helps one hundred percent.

Most analogues are highly bioavailable. Almost all generics, like the original Kapoten, quickly accumulate in the body. That is, the effect of the medicine can be felt on yourself no longer than 15-20 minutes after taking it. And at the same time, many analogues, like Kapoten, are eliminated too quickly from the body, which is why their daily dose is slightly increased.

To tell you what to replace Kapoten with, you definitely need a specialist who realistically assesses the condition of the body. He will determine the necessary daily dose of the medicine. When starting treatment, it is very important to remember that the effect of Kapoten can be achieved only with its regular intake - if you feel relief from one pill, you should not stop the wellness course.

Side effects

  1. From the digestive tract: nausea, vomiting, constipation.
  2. Impact on hematopoiesis: inhibition of blood growth.
  3. Nerve pathologies: depression, ataxia.

It differs from Kapoten in the composition and mechanism of action. It has a hypotensive effect and dilates blood vessels. It has a low cost.

Kapoten Russian analogue | Heart Treatment

| Heart Treatment

Problems with high blood pressure, unfortunately, are not so rare. Most often, pressure torments older and middle-aged people, but sometimes young people also have to escape from an ailment. Kapoten and its analogues will help to cope with attacks of hypertension and will contribute to their prevention in the future.

What is Kapoten for?

This medication has established itself as an excellent ACE inhibitor. Thanks to Kapoten, the formation of the substance of angiotensin II, which has a vasoconstrictor effect, is stopped. And due to this, accordingly, the pressure normalizes.

The main active ingredient in Kapoten is captopril. In pharmacies today you can find tablets containing 25 or 50 milligrams of this substance. The dosage is selected depending on the problem and the general state of health of the patient. And only a specialist should do this.

Kapoten boasts a fairly large number of advantages:

  1. The medicine significantly reduces the mortality rate from diseases of the cardiovascular system.
  2. The drugs act very effectively and at the same time quite accurately. Kapoten and generic drugs do not affect the nervous system. And men can take medications without worrying about a decrease in potency.
  3. And Kapoten, and its analogues favorably affect the health of the kidneys, slowing down the destructive processes in them. Often, the drug is prescribed even with nephropathy of diabetic origin.
  4. A huge plus of Kapoten and most of its analogues is accessibility.

Restrictions on the use of drugs

Determining the difference between Kapoten and Captopril, it is necessary to study their side effects and contraindications. Kapoten is believed to be safer, but it has the same side effects as Captopril.

As for contraindications, in this case the differences between these agents are insignificant. You can not use drugs in the following cases:

  • individual intolerance to the main active substances that are part of the medication,
  • hypotension
  • kidney and liver problems
  • pregnancy and lactation
  • weakened immunity, various immunological diseases,
  • under the age of 16 years.

Both medicines are considered potent, so their uncontrolled use is prohibited. It is necessary to take into account the compatibility of both drugs with other drugs. When combined with a drug such as Nifedipine, the hypotensive effect will increase. The patient should be under real supervision. It is better to replace the drug with other drugs.

Side effects of the drug

Side effects that are associated with the work of the nervous system are as follows:

  • dizziness appears
  • my head starts to hurt all the time,
  • a person feels tired and drowsy,
  • in rare cases, vision deteriorates.

As for the heart and blood vessels, Captopril, whose analogues are very diverse, can cause an increase in heart rate, but this is extremely rare.

With Kapoten, not only does the pulse rate increase, but also because of the drug, hypotension and swelling appear.
A negative effect can be exerted on the digestive system.

Captopril can cause a decrease in appetite, loss of ability to distinguish taste, pain in the abdomen, stool changes. With Kapoten, the side effects are as follows:

  • diarrhea,
  • stomach ache,
  • changes in taste
  • numbness of the tongue
  • drying out of the mucous membranes of the mouth,
  • stomatitis,
  • hepatitis (in rare cases).

Both drugs affect the respiratory system: Captopril can cause a dry cough in a patient, the difference is that Kapoten can also provoke a cough, but if you take it, cramps and pulmonary edema may develop. In rare cases, both drugs cause bleeding, which leads to anemia. Sometimes patients have an allergic reaction in the form of swelling, rash, redness.

Difference between drugs

If you compare Captopril with Kapoten, you can find minor differences. Despite the same active substance, the auxiliary compounds in the preparations are different. This does not affect the effect of the medication - both are considered effective.

But with the side effects may be slightly different due to the auxiliary components in the composition of the drugs. One of the medicines contains talc, and this can negatively affect the body. It should be borne in mind that despite the same effect of drugs on a person, prices differ significantly.

This is also due to the composition: in one of them there are fewer excipients, and the medicine is cheaper due to the lower cost of its production.

Captopril and Kapoten have many analogues, so you can always choose a more suitable option. The main thing is to consult a doctor before doing this. In no case should you self-medicate.

What is better - Enalapril or Captopril, a question that worries many people. Both medicines are considered analogues of each other. Both drugs belong to the same group of drugs and have similar properties. It doesn’t really matter if you take captopril or enalapril. Both medicines reduce pressure, help improve the condition of the heart muscle in a chronic form of insufficiency.

However, Anaprilin, like Enalapril, differs slightly from Captopril. For example, if the patient has a moderate or mild form of hypertension, Enalapril is enough to use only 1 time per day, and Captopril will have to be taken up to 3 times a day, since the period of action of the active components of the drug is shorter.

In addition, the first medication will be better to maintain blood pressure at the required level with prolonged use. So enalapril is the best option if you need to maintain pressure for a long period of time.

As for Captopril, its administration will be advisable when it is only necessary to periodically reduce high blood pressure.

  • high bioavailability of the drug compared to analogues,
  • rapid accumulation in the body, and accordingly the rapid achievement of a therapeutic effect,
  • low price in comparison with analogues
  • a convenient form of release of the drug in a jar,
  • There is a choice of the dosage of the drug - tablets of 25 and 50 mg.

  • quickly excreted from the body, which contributes to an increase in the frequency of administration of the drug per day.

Release form and recommended prices:

  • Kapoten® tablets 25 mg, 28 pcs.

* The maximum permissible retail cost of medicines is calculated, calculated in accordance with Decree of the Government of the Russian Federation No. 865 of October 29, 2010 (for those medicines that are on the list)

Instructions for use:

The tablets are taken orally, on an empty stomach, washed down with a small amount of cool, clean water.

With mild to moderate degrees of arterial hypertension (140 - 170/90 - 100 mm Hg. Art.), The drug is prescribed at 12.5 mg 2-3 times a day. The maximum daily dose is 100 mg.

In severe arterial hypertension (from 180/90 - 100 and above), the drug is prescribed initially at 25 mg 3-4 times a day, then, if necessary, the dose is increased to 50 mg 3 times a day. The maximum daily dose should not exceed 150 mg of the drug.

In heart failure, the drug is prescribed at 6.25 mg 2-3 times a day, if necessary, increase the dose to 25 mg 3-4 times a day. The maximum daily dose of the drug is 150 mg.

With myocardial infarction, the drug is prescribed at 6.25 mg 2-3 times a day, if necessary, increase the dose to 25 mg 3-4 times a day. The appointment of the drug should be made 3 days after the onset of the disease. The maximum daily dose of the drug is 150 mg, divided into 3 doses.

In diabetic nephropathy (kidney disease in diabetes mellitus), the drug is prescribed at 57 - 100 mg 2 to 3 times a day. The maximum daily dose is 300 mg of the drug.

In case of impaired renal function, the drug is prescribed at 12.5 mg 2-3 times a day, with the ineffectiveness of this treatment, the dose is gradually increased to 75-100 mg 2-3 times a day. The maximum daily dosage is 300 mg, divided into three doses.

The course of treatment is selected individually for each patient and is conducted under the supervision of a physician.

During pregnancy and lactation, the drug for use is prohibited.

Safety and efficacy of the drug in children have not been studied.

Conclusion

With high blood pressure, coronary heart disease, heart failure and other pathologies of the cardiovascular system, Kapoten's analogues and substitutes will help to get rid of.

List of the most effective substances:

1. Captopril Sandoz - the fastest drug, helps with crisis conditions, protects the heart muscle.

2. Tenzotran - An analogue of a new generation to combat hypertension and hypertrophic changes in the myocardium.

3. Enalapril - A reliable tool for reducing blood pressure and preventing cardiovascular pathologies.

4. Andipal - the cheapest domestic substitute for the comprehensive achievement of antihypertensive and analgesic effects.

However, the funds listed above should only be prescribed by a doctor after an individual consultation. Self-medication and self-administration is prohibited and can cause serious complications and side effects.

Comparison table

Drug nameBioavailability,%Bioavailability, mg / lTime to reach maximum concentration, hHalf-life, h
Kapoten70 – 8070 – 890,3 – 11,5 – 2, 5
Captopril77 – 8978 – 990,3 – 21,5 – 3
Angiopril80 – 8671 – 790,3 – 21– 2, 5
Blockordil80 – 9082 – 950,5 – 11– 2, 5
Catopil84 – 9584 – 960,5 – 22 – 2, 5
Epsitron69 – 7070 – 791 – 21,5 – 3,5

At what pressure do Kapoten drink: instructions, price and analogues

From this medical article, you can find the drug Kapoten. Instructions for use will explain in which cases you can take pills, what the medicine helps with, what indications there are for use, contraindications and side effects. The annotation presents the form of the drug and its composition.

In the article, doctors and consumers can leave only real reviews about Kapoten, from which you can find out whether the medicine helped in the treatment of hypertension and lowering high blood pressure in adults and children. The instructions list Kapoten's analogues, the prices of the drug in pharmacies, as well as its use during pregnancy.

Pharmachologic effect

Kapoten is an ACE inhibitor. It inhibits the formation of angiotensin II and eliminates its vasoconstrictor effect on arterial and venous vessels.

The drug reduces OPSS, afterload, lowers blood pressure, and also reduces preload, reduces pressure in the right atrium and pulmonary circulation.

Kapoten, instructions for use confirm this, reduces the production of aldosterone in the adrenal glands.

The peak of effectiveness is observed 60-90 minutes after ingestion. The degree of decrease in blood pressure is the same in the patient's standing and lying position.

When taken with food, absorption of the drug slows down by 30-40%. The elimination half-life makes 2-3 hours. The drug is excreted in the urine up to 50% - unchanged, the rest - in the form of metabolites.

What helps Kapoten?

Indications for use of the drug include:

  • violations of the function of the left ventricle after myocardial infarction in a clinically stable condition,
  • chronic heart failure (as part of combination therapy),
  • diabetic nephropathy with type 1 diabetes mellitus (with albuminuria> 30 mg per day),
  • arterial hypertension, including Renovascular.

Special instructions

In patients with arterial hypertension, when using the drug, severe arterial hypotension is observed only in individual cases, the likelihood of developing this condition increases with excessive loss of salts and fluid (for example, after intensive diuretic therapy), in patients undergoing dialysis or in patients with heart failure.

The possibility of a sharp decrease in blood pressure can be minimized if diuretics are canceled in 4-7 days or the sodium chloride intake is increased in advance (in 7 days). This can also be achieved by prescribing small doses of Kapoten at the beginning of treatment (6.25-12.5 mg per day).

Drug interaction

Kapoten can potentiate the hypotensive effect of diuretics. An excessive decrease in blood pressure is possible with strict restriction of salt intake, hemodialysis and usually occurs within the first hour after taking the first prescribed dose of the drug.

During therapy, vasodilators should be used at the lowest effective doses due to the risk of an excessive decrease in blood pressure. With the combination of Kapoten and drugs that affect the sympathetic nervous system, caution should be exercised.

Differences in Drug Composition

Having studied the instructions for the use of drugs, we can assume that they are almost identical in composition. At the same time, Kapoten has a much higher cost than Captopril. Cardiologists often recommend the first medicine to their patients, basing their choice on the more pronounced therapeutic effects of the drug.

Captopril 25 mg tablets

The main differences are in the composition of drugs. Here the difference is obvious. It's all about excipients.

The composition of Kapoten includes:

  • corn starch,
  • lactose or milk sugar,
  • microcrystalline cellulose,
  • stearic acid.

Captopril contains a more extensive list of additional ingredients:

  • talc,
  • potato starch,
  • lactose,
  • microcrystalline cellulose,
  • polyvinylpyrrolidone,
  • magnesium stearate.

The frequent development of side effects from taking Captopril is due precisely to the toxicity of talc, which is used as a soft absorbent.

As you know, this substance has carcinogenic properties and can provoke the development of cancerous tumors. In addition, it has a negative effect on the condition of the genital area and impairs the functioning of the kidneys, lungs, and liver. Talc is often the main cause of pathological processes in the blood system.

Captopril is considered a more “pure” drug, which affects its low cost.

Despite the loyalty of the price, most specialists do not see a difference in the effectiveness of drugs, therefore, both drugs are prescribed with the same frequency, based on the financial situation of patients, their negative reactions to talc and the body's resistance to drugs.

When can you not use drugs?

Captopril group preparations are categorically contraindicated in a number of cases, including:

  • different forms of renal failure or severe pathologies of the urinary tract,
  • gross liver dysfunction,
  • individual intolerance to the main active substance or auxiliary components of the agent,
  • immunodeficiency states and a sharp decrease in immunity,
  • hypotension and a tendency to a sudden drop in blood pressure.

Characteristics of drugs

The active active ingredient of the drugs is captopril, a sulfhydryl compound. When ingested, it blocks the production of angiotensin, a hormone produced by the liver.This hormone is responsible for the state of the vessels - spreading through the bloodstream, increases the tone of the walls. The more it is, the higher the likelihood of developing hypertension. Lumen of blood vessels narrow, respectively, blood pressure increases.

If angiotensin synthesis is inhibited, cramping does not occur. Smooth muscles relax at the same time, the body relieves excess fluid, and the pressure decreases.

The effect of captopril is not limited to the hypotensive effect. Regular intake:

  • isolates free radicals plying in the lumen of blood vessels, promotes natural excretion by the kidneys,
  • increases the speed of coronary and peripheral blood flow,
  • increases insulin sensitivity, which means it normalizes blood sugar.

Auxiliary components of Kapoten and Captopril are also similar - lactose monohydrate, modified starch, stearic acid, cellulose. There are no differences in effect - they reduce the level of blood pressure, that is, both drugs have antihypertensive properties. They can be used both at an early stage of hypertension, to maintain the working level of blood pressure, and to stop crises.

When choosing, it should be based not only on qualitative characteristics, but also on individual perception.

This drug, named for its active ingredient, was launched earlier. In 1975, the active substance was synthesized in the United States, the laboratory of the pharmaceutical company Squibb, and after 10 years it was launched into production. In Russia, the medicine began to be sold since 1993. Available in the form of white tablets in 2 types - 25 and 50 mg of captopril.

Indications for appointment:

  • hypertension - arterial and renovascular,
  • chronic heart failure.

Action: reduces the rate of transformation of angiotensin form 1 into 2, prevents vascular spasm, increases renin activity in the blood plasma, reduces the load on the cardiovascular system, normalizes protein-lipid metabolism, and accelerates blood flow. In addition, it prevents the development of bradycardia, and prevents the formation of blood clots, reducing platelet aggregation.

It is recommended to take before meals, for 15-30 minutes. The maximum distribution in blood plasma 50 minutes after oral administration, is absorbed by 75% and binds to blood proteins, albumin by 25-30%. The half-life of 3 hours. It is excreted 95% with urine, 45% unchanged, the rest is in the form of metabolites.

Increase the dosage gradually:

  1. With arterial hypertension, they start with 25 mg of the substance twice, in the morning and in the evening, gradually increase to 50 mg by the second week. In severe cases, taking three times.
  2. In chronic heart failure, they are used together with diuretics, if the therapeutic effect is insufficient. The initial dose is half less than with arterial hypertension, then increased to 25 mg.

The maximum daily dosage for the active component is 150 mg.

ACE inhibitor is available only in tablets of 25 mg relative to the active substance. After oral administration, the effect is felt after 15-45 minutes, with a reduced metabolism after 1.5 hours. There are no differences between Capoten and Captopril in pharmacokinetic and pharmacodynamic properties. The half-life is the same, the discharge is similar - that is, 85% with urine. But it is recommended to take a slightly different scheme, it is better 1 hour before a meal.

  • relieves vascular spasm
  • reduces the load on the heart muscle,
  • reduces pressure in the right atrium,
  • normalizes the production of aldosterone - a mineralocorticosteroid hormone produced in the adrenal cortex.

What is the difference between Captopril and Capoten, you can see the recommended dosage:

  1. With hypertension - start with half a tablet, 12.5 mg, gradually increasing - if necessary - up to 4 tablets per day, 100 mg.
  2. In chronic heart failure, they initially take 6.25 mg, increasing to 150 mg within 24 hours.
  3. With diabetes - you can immediately start with a double dose of 50 mg.
  4. In diabetic nephropathy, it is recommended to start with 75-100 mg per day, dividing the daily dose into several doses.

After myocardial infarction, they are introduced into the therapeutic course for 3 days. If the doctor has not made a special purpose, then take as in chronic heart failure.

Is there a difference in efficiency?

Both drugs have a pronounced hypotensive effect, so they quickly reduce high blood pressure.

Only the attending physician can give a definite answer to the question of which drug is best for a particular patient, relying on the results of the examination, taking into account the degree of neglect of the pathological process, and also taking into account the individual characteristics of the patient’s body.

The appointment of Captopril, Kapoten preparations should be carried out by an experienced specialist, since self-medication is fraught with the development of complications of the main ailment and side reactions that significantly aggravate its course.

In the Cossacks of an alternative option, they can help figure out which is better - Kapoten or Captopril, reviews of patients who were treated by them.

What is more effective?

The main effect is determined by the main component - captopril. Its properties:

  • reduces vascular resistance,
  • increases myocardial endurance,
  • lowers blood pressure
  • increases cardiac output,
  • improves well-being.

Indications for the drugs are the same, but captopril contains the main substance in its pure form, therefore side effects are less and less common. But, on the other hand, excipients of Kapoten reduce the risk of undesirable effects in the presence of other diseases, soften the effect.

In addition, the difference is also in the degree of purification of the components. Kapoten is produced in America, where this process is better than that of domestic captopril. Hence the price difference. Both drugs are effective, but which one is preferable, the doctor decides.

Which drug is better

When choosing a medicine, focus primarily on the recommendations of your doctor. If he believes that Kapoten will be the best option, do not hesitate to buy the medicine.

If your doctor has no objection to the replacement, in this case you can take Captopril - it is much cheaper, but not worse than the analogue.

In any case, when choosing a tool, please note:

  1. Kapoten differs from Captopril in name, price and manufacturer, which does not affect the effectiveness or medicinal properties.
  2. The drugs have one active substance - captopres, it determines the similarity of indications and contraindications for use, side effects, interactions with other drugs and the mechanism of action.
  3. The main purpose of the drugs is a long-term treatment of hypertension, they are not recommended to be used as an emergency aid (for example, to reduce sharply increased pressure, for this the doctor will advise other means).
  4. The drugs have a pronounced hypotensive effect (lower blood pressure) only if they are regularly used in the dosage prescribed by the doctor.

Composition

In order to understand how the medicine works, you need to find out what it consists of. One Andipal tablet contains 4 main substances:

  • phenobarbital - 0.02 g,
  • papaverine hydrochloride - 0.02 g,
  • bendazole - 0.02 g,
  • sodium metamizole or analginum - 0.25 g.

In addition to them, the preparation contains auxiliary components that do not affect the medicinal properties:

  • talc,
  • calcium stearate
  • potato starch,
  • stearic acid.

Each of the active ingredients of Andipal is important, performs its function and provides the desired effect:

  1. Metamizole sodium, known as analgin, forms the basis of the drug.It quickly relieves the headache that bothers a person with high blood pressure.
  2. Papaverine hydrochloride is able to eliminate painful spasms of blood vessels, reduce heart rate. The substance is indicated for use by hypertensive patients as an antispasmodic.
  3. Bendazole or dibazole acts as a vasodilator and sedative, but apart from other components, it cannot affect blood pressure.
  4. Phenobarbital has a pronounced sedative effect. It helps to relieve the patient’s nervous state caused by hypertension.

Indications for use

For a long time, the indication for taking Andipal was the presence of signs of high blood pressure, but more effective drugs are now available that are used to treat hypertensive crisis. However, it remains a popular drug that is prescribed by doctors in the presence of the following symptoms:

  • migraines of various etiologies,
  • cerebrovascular spasms,
  • pain syndrome caused by spasms of the smooth muscles of the digestive tract,
  • initial stage of hypertension.

It is not recommended to start using the medicine without confirming the diagnosis. In some cases, when high blood pressure is associated with other serious illnesses, other drugs and treatments are used for them. If you do not pass a full examination, Andipal will only relieve pain, contributing to the development of complications.

What do drugs have in common?

Both drugs have the same picture of the effect on the body, with a comparable dosage. Tablets can be taken by both a child and an adult. Only the dosage and frequency of administration are changed.

An essential common feature is the positive effect when stopping pain syndromes with hypertensive crises. After several receptions, the patient feels an improvement. The main thing is to take drugs regularly, as required by the instructions.

Andipal and Kapoten are also excellent medications in the treatment of acute heart failure. Combination of the drug with the main course of treatment is allowed.

Analogs of drugs

Kapoten and captopril have many analogues that are similar in effect, when changing a medicine, to avoid addiction, doctors still recommend drugs such as:

  1. Rilcapton. The main substance is captopril - 25 mg. It is prescribed for hypertension, acute heart failure, disruption of the left ventricle after a heart attack, diabetic nephropathy. Store at temperatures up to 25 degrees. The price is 150 rubles.
  2. Alkadil. From a series of ACE inhibitors. The main substance is captopril, 25 mg. It is prescribed for hypertension, acute heart failure. Store no more than 5 years, at a temperature of 10 to 25 degrees. The price is about 200 rubles.
  3. Kaptopres. In 1 tablet - 50 mg of captopril and, depending on the dosage, 25 or 12.5 mg of hydrochlorothiazide. Of the auxiliary substances - magnesium stearate, starch, aerosil, milk sugar, povidone. It copes with hypertension, hypertension on the background of bronchial asthma, heart failure, diabetic nephropathy. Store no more than 3 years at a temperature of up to 30 degrees. Price - from 90 to 200 rubles.

What is the difference?

These drugs belong to different pharmacological groups. Andipal - angiotensin converting enzyme (ACE) inhibitors and β-blockers. As for Kapoten, it is a calcium channel blocker and sympathicolytic. Kapoten is a substance with a pronounced vasoconstrictor effect.

If we consider them from the point of view of efficiency, then Andipal begins to act already after 3 hours, and the period of exposure to the body is limited to seven hours. Kapoten, due to the need to take 3 times a day, has a shorter period of exposure to the body, namely 5:00.

A cardinal difference is the fact of the possible intake of Kapoten by people who suffer from bronchial asthma or diabetes. If renal failure occurs, a doctor's consultation is necessary. Both drugs are not recommended for use if cerebrovascular insufficiency is diagnosed.

Drug differences

Excipients used for the manufacture of pharmaceuticals to stabilize blood pressure differ in composition, albeit slightly. Captopril has polyvinylpyrrolidone, a water-soluble polymer that is used as a surface coating. Due to fewer additional components, Kapoten causes fewer side effects. These include: weakness, drowsiness, dizziness, drying out of the mucous membranes of the nasopharynx, skin rash and anemia - with prolonged use.

Captopril has many more side effects. In addition to the already listed signs of intolerance, we noted: numbness of the tongue, impaired swallowing function, tachycardia, abdominal pain and diarrhea, impaired sense of taste. Immediately after refusing to take the condition is not restored - the drug has a prolonged effect. Sometimes you have to seek help from a doctor.

But to choose which is better, Kapoten or Captopril, even when a history of polyvalent allergy, you still have to do it yourself. There is an opinion that the difference in fillers does not affect the effectiveness. In addition, various pharmaceutical companies are changing the composition of additional components.

Official studies have proven that cellulose accelerates the absorption and absorption of the active compound. But manufacturers often reduce the amount of this substance due to the remaining components.

There is another difference - this is the price. Captopril is 4-5 times cheaper. The cost of packaging (40 tablets) is 12-60 rubles, depending on the manufacturer. Kapoten is a patented product, and packaging is not appreciated for less than 200-250 rubles. Many patients believe that a good drug cannot be cheap, and prefer the latter.

Comparison of drugs by doctors

Doctors note that there is no particular difference between capoten and captopril, both well lower the pressure, keep it normal. Which drug is better in a particular case, you need to decide, depending on the results of the examination of the patient, taking into account the stage of the disease and the characteristics of the body.

Who is better suited to?

Both drugs can be taken by both children and adults. Based on the information contained in the instructions, Andipal is better for teens and children.

The latter contains a natural analgesic with antipyretic properties - metamizole. As for Kapoten, it is an excellent vasodilator and pain medication.

A similar concomitant effect on the body will be useful to people of advanced age.

Replaceable

Due to some difference in composition, the drugs are not transferred equally. Replace one with another, not only on the basis of individual perception, but also for other reasons. For example, due to a lack of pharmacy or unwillingness to overpay. In the instructions for use, there is no indication that Kapoten should not be replaced by Captopril or vice versa. But they can’t be used together.

In this case, a high probability of an overdose:

  • stupor,
  • state of shock
  • an attack of hypotension (the development of acute symptoms is possible: vomiting, impaired consciousness, a collaptoid state, turning into a coma),
  • heart rhythm disturbance - bradycardia.

One of the most dangerous complications is acute renal failure. Urine output is reduced to 0.5 liters per day.

In case of an overdose caused by co-administration at home, it is necessary to rinse the stomach, causing vomiting, and offer the victim an enterosorbent (Atoxil, Polysorb Enterosgel). A sharp drop in pressure is a good reason to call an ambulance.In this case, it is necessary to infuse funds that restore heart rhythm. Hemodialysis may be required.

Practitioners have an opinion on which medicine to prescribe to each patient. Which is better, they determine from their own experience.

Azimov S.S., cardiologist, Kostroma:

I have never encountered an allergy or intolerance to Kapoten. I believe that even in the initial stage of hypertension, this medicine should always be at hand. In the event of a crisis, it will quickly help normalize the condition. But I immediately warn you that you should not rely on the effectiveness of elderly people - with a slow metabolism.

Vilkova V.A., therapist, Kazan:

If you had to vote, I would choose Captopril. But patients always warn that the dosage must be observed. Only then can you take a long time - up to 4-6 months. When I notice that addiction has appeared, and the dosage should be increased, I independently select an analogue. But I suggest using Kapoten as an ambulance.

Sergeev Yu.V., cardiologist, Yuryuzan:

I advise you to take both funds only in emergency cases. If long-term treatment is required, selecting other drugs. I did not encounter an acute allergy to captopril, but I often heard complaints about side effects - dry mouth, sore throat.

Patient reviews are also different. Therefore, it is not worthwhile to say what is worse and what is better, based on the opinions of those who have tried these funds. But still, one should take into account the experience of others.

Irina Yurievna, 64 years old, Moscow:

I have known hypertension since I was 40. There were acute crises, they were hospitalized several times. Advised Kapoten. I have been taking it for 4 months. Started with 0.5 tablets in the morning and evening, gradually increased the dose to 4 pieces per day. I feel much easier - shortness of breath has passed, there is no feeling of constant fatigue, the pressure returned to normal. But the neighbor taking Captopril constantly complains of a dry mouth. But she is not able to buy an analogue of more expensive.

Alina Ivanovna, 47 years old, Ufa:

Not a single captopril drug has helped - neither expensive nor cheap. Pressure "jumped", the head constantly hurt, irritation grew. I had to pick up another drug.

Andrei Vladimirovich, 74 years old, Ishimbay:

Problems with pressure started early, interfered with professional activities, created a problem in the family. I tried many antihypertensive drugs. The penny Captopril began to take in despair - nothing helped. Within a week I noticed a significant improvement, blood pressure was stable, 130/80. I do not increase the dosage. As the doctor prescribed 2 tablets in the morning and at bedtime, I take it. During a break in a therapeutic course, he also carried with him all the time - used to stop crises.

If the drug for pressure is not the only remedy that you have to take regularly, when choosing between Captopril and Capoten, you need to consult a therapist. It is possible that one of the forms of the active substance is not combined with other drugs, or you need to switch to an analogue.

Patient reviews

Valeria, 39 years old, hypertensive. I tried both kapoten and captopril. The hood helps me more, it reduces pressure faster, there are no side effects.

Nina, 52 years old, hypertensive. I have been bathing with pressure for a long time, the doctor advised me to try both hoods and captopril, which is better. Kapoten helps me better, even half a pill is enough to relieve pressure. It does not dry, the head does not hurt. More delicate drug.

Natalia, 62 years old. My husband has high blood pressure, all the time knocked down by a hood. But very expensive. Consulted with a doctor, he allowed to try captopril. When once again the pressure jumped to 160, my husband drank the pill, and after half an hour fell asleep. In the morning I got up in good condition. So we switched to captopril and are quite satisfied.

Summing up, it is worth noting that both drugs - both capoten and captopril - are very effective. Similar in composition, with largely coinciding indications and contraindications. After consulting with a doctor, you can try both in turn, and decide which one is more suitable for the body: in its pure form or with additives.

Online magazine about choosing the best products and services

Updated: 06.08.2019 18:44:18

Expert: Lev Sagalovich

Not a single person is safe from high blood pressure. Strong stress, unusual physical activity, a sharp change in climate - and now my head is already breaking, and the mark on the tonometer is inexorably creeping up. Such a nuisance can happen even against the background of full health.

So what about those for whom hypertension is a diagnosis recorded in a medical record? This category of patients can not do without antihypertensive drugs - effective, reliable and safe agents that can lower blood pressure and prevent the development of a crisis.

In the treatment of hypertension and other concomitant pathology of the cardiovascular system, various drugs are used. Among them, two remedies deserve special attention - Andipal and Kapoten. They are more often found in the medicine cabinet hypertonic. Many people hesitate to leave home without an emergency pill. But are these remedies so good as they are said?

Andipal and Kapoten are drugs that lower blood pressure. On this, the similarity of the funds in question ends.

The experts of our journal studied the composition of antihypertensive drugs, got acquainted with the clinical trials and found out that their composition and principle of action are fundamentally different. We found that, according to modern concepts, in the treatment of hypertension, Kapoten is more often prescribed.

Andipal is gradually becoming a thing of the past, and its use under high pressure is not always justified. Let's see why this happens and why cardiologists prefer Kapoten.

Mechanism of action

The active component of Captopril and Kapoten is an inhibitor (inhibitor of the chemical reaction) of the angiotensin enzyme.

This substance causes a narrowing of the blood vessels and enhances the production of the hormone by the adrenal glands, which is responsible for the retention of water in the tissues (aldosterone).

Thus, taking medications with captopril helps to expand the arteries and, accordingly, reduce the blood pressure in them. Slowing down the synthesis of aldosterone, tablets also have a diuretic effect and eliminate swelling.

What's inside? Compare the composition of the drugs

Andipal is a combination drug. It belongs to the group of antispasmodics. In its composition such components are declared:

bendazole (20 mg) - a vasodilator,

metamizole sodium (250 mg) - analgesic and antipyretic,

papaverine hydrochloride (20 mg) - antispasmodic,

phenobarbital (20 mg) - a psychotropic drug.

Such a complex composition explains the fact that Andipal is used for various pathological conditions and is used not only for hypertension. Each of these substances will be considered in more detail below.

Kapoten is a monocomponent preparation. It belongs to the group of ACE inhibitors (angiotensin-converting enzyme). The active substance is captopril (25 mg). Other components in the composition of the drug are not stated.

Both drugs are available in pill form. They are dispensed in pharmacies without a doctor’s prescription. Cost varies by region. On average, Kapoten’s packaging will cost 250-350 rubles (56 pcs.). Andipal is cheaper - 10 tablets cost only 9-12 rubles.

Kapoten characteristic

Kapoten is an ACE inhibitor. The drug prevents the conversion of inactive angiotensin-2 to active angiotensin-1. This substance has a pronounced vasoconstrictor effect.The antihypertensive effect of captopril is due to a decrease in the concentration of angiotensin-2 in the blood.

In this case, the synthesis of aldosterone decreases and bradykinin accumulates (this substance contributes to the expansion of blood vessels). Kapoten reduces peripheral vascular resistance, in which a sharp increase in blood pressure is possible.

The drug has the following pharmacological effects:

  • reduces total peripheral vascular resistance,
  • increases cardiac output while maintaining the overall heart rate,
  • increases myocardial endurance,
  • lowers blood pressure
  • has a cardioprotective (protective heart) effect,
  • improves overall well-being,
  • normalizes sleep, improves its quality,
  • improves the overall emotional state of a person,
  • slows down the development of kidney failure,
  • in patients with chronic kidney failure, reduces the need for dialysis,
  • does not allow the development of complications of diseases of the cardiovascular system, including a stroke.

Kapoten is characterized by high bioavailability, and the maximum content of the active substance in the blood is reached within an hour after oral administration. The elimination half-life is 2 hours, while the bulk of the drug is excreted from the body during the day. It is metabolized in the body with the formation of inactive decay products. With kidney diseases, the half-life of this medicine is slightly increased.

The drug is indicated for:

  • cardiac output disorders,
  • arterial hypertension
  • chronic heart failure
  • violations of the function of the left ventricle of the heart,
  • diabetic kidney damage,
  • some varieties of coronary heart disease,
  • severe hypertension with a tendency to hypertensive crises,
  • cardiomyopathies.

The medicine is prescribed for long-term prophylaxis of heart failure.

The maximum content of the active substance in the blood is reached within an hour after oral administration of Kapoten.

The method of application of Kapoten is set individually. The dose ranges from 25 to 150 mg per day (in the latter case, the dosage is divided into several doses). With hypertensive crisis, Kapoten sublingual administration is indicated. To do this, 1 tablet of the drug is placed under the tongue.

The dosage is set so that the total amount of the drug does not exceed 0.15 g per day.

With a heart attack, the drug is taken as soon as possible after the appearance of the first signs of an attack. The dose in this case is slowly increasing. The duration of Kapoten therapy is no more than a month, after which the doctor develops a new treatment regimen.

With renal failure, either the dose decreases, or the intervals between doses of the drug increase. For elderly patients, the minimum recommended dose is prescribed.

Kapoten causes such adverse reactions:

  • the appearance of a small point rash in different areas of the skin,
  • various taste changes
  • an increase in the amount of protein in the urine,
  • decreased blood creatinine,
  • a decrease in the number of white blood cells,
  • a decrease (up to the absence) of granulocytes in the blood.

Kapoten is contraindicated in:

  • hypersensitivity of the body to the drug (a strong allergic reaction may develop),
  • pronounced tendency of the patient to edema,
  • body condition after kidney transplantation,
  • narrowing of the lumen of the aorta,
  • narrowing of the lumen of the mitral valve,
  • primary hyperaldosteronism (increased release of aldosterone due to overgrowth or tumor of the adrenal gland),
  • accumulation of fluid in the abdominal cavity,
  • pregnancy
  • breastfeeding.

Kapoten is not prescribed to children until they are 14 years old. Patients who have reached this age are treated exclusively under the supervision of a doctor. This medicine is also prohibited for those patients whose activity is associated with a constant strain of attention or requires increased concentration.

Release forms and price

Captopril in tablets is produced by many Russian and foreign pharmacological enterprises. Accordingly, the price of a medicine with the same dosage and quantity can vary:

  • 25 mg, 20 pcs. - 13-94 rubles.,
  • 40 pieces - 20-146 rubles,
  • 50 mg, 20 pcs. - 41-45 rubles.,
  • 40 pieces - 52-67 rubles.

Kapoten tablets are the products of the domestic pharmaceutical company Akrikhin. The dosage is always the same (25 mg), and the cost is determined by the amount of drug in the package:

  • 28 pcs. - 169 rub.,
  • 40 pcs. - 230 rub.,
  • 56 pieces - 315 rubles.

From pressure

Captopril and Kapoten have been used for a long time to treat high blood pressure. The duration of therapy is sometimes a year or more. All this time, patients monitor the regularity of the drug. It is forbidden to arbitrarily reduce or increase the dosage, because this sometimes leads to irreparable consequences.

When prescribing these drugs, they carefully monitor which drugs the patient is taking additionally (some of them adversely affect the effectiveness of Captopril, Kapoten).

Each tablet has its own time, or when drugs are prescribed

Kapoten is the only representative of ACE inhibitors, which is used for emergency care for hypertensive crisis.

It acts quickly and can be prescribed with a sharp rise in blood pressure. Kapoten is the drug that every hypertonic should have in his medicine cabinet.

The rapid development of the effect is extremely important for the prevention of dangerous complications of hypertension - stroke and myocardial infarction.

According to the recommendations of leading Russian cardiologists, captopril is also prescribed for the course treatment of such conditions:

arterial hypertension, including those associated with kidney pathology,

coronary artery disease,

chronic heart failure

condition after myocardial infarction,

Andipal is not declared as a means with a direct hypotensive effect. It acts more as an analgesic and antispasmodic against the background of certain conditions:

impaired blood flow in the brain,

digestive tract diseases.

Andipal acts more slowly, it is not used with a sharp increase in blood pressure to high numbers. In practice, this drug is usually prescribed in the treatment of mild hypertension - with 1 degree of hypertension.

Cardiologists do not use Andipal in cases of severity 2 and 3, as well as in the presence of concomitant serious diseases of the heart and blood vessels. It is not recommended to drink the medicine for more than 10 days in a row - this increases the risk of complications.

The subtotal is: Kapoten directly affects the mechanisms of increasing blood pressure and eliminates them. Andipal affects only some links of hypertension, relieves the symptom (high pressure), but does not eliminate the cause of its appearance. In the long run, the Kapoten effect will be more noticeable.

How to take?

Andipal is prescribed orally, preferably after a meal. The daily dosage of the drug is divided into 2-3 doses, depending on the severity of the patient's condition. Do not change the dose indicated by your doctor.

Kapoten is also taken orally after a meal. With a sharp increase in pressure, you need to carefully chew or dissolve one tablet - so captopril penetrates the blood faster through the mucous membranes.

Practical experience shows that after 20 minutes the pressure decreases by 15%, by the end of the first hour - by 20%. If the effect is not too noticeable, you can take another pill in an hour.

If, in this case, the drug does not help, consult a doctor as soon as possible.

For the course of treatment, Kapoten is prescribed 2-3 times a day. Taking the drug begins with a minimum dose - usually ½ tablet. If necessary, the dosage is gradually increased to that at which the pressure will remain within normal limits.In old age and with severe kidney pathology, a lower dosage of the drug is usually used.

Foreign clinical guidelines clearly state: antihypertensive drugs should be taken with statins - cholesterol lowering agents. Statins cleanse blood vessels and regulate lipid metabolism. In hypertensive patients, cholesterol levels should not go beyond the age norm.

The opinion of doctors

Irina, cardiologist, 50 years old, Moscow: “For severe forms of arterial hypertension, I prescribe Kapoten to patients. I choose the dosage individually, taking into account the form of the disease, the duration of its course and other factors. Most often, patients tolerate treatment with Kapoten well: they rarely have side effects. Patients carefully observe the treatment regimen, diet, engage in feasible physical activity. This helps maintain normal blood pressure. ”

Valeria, therapist, 44 years old, Ulyanovsk: “For patients with hypertension and prevention of complications of this disease, I prescribe Captopril to patients. I recommend the long-term (from six months) use of the drug. I choose the minimum effective dosage in order to prevent the body from getting used to and switching to stronger drugs. I recommend it for short-term and one-time care for hypertensive crisis. Subject to the rules for taking Captopril, its side effects are extremely rare. ”

How are they carried?

Andipal cannot be called a safe drug. Health risk is determined by its components:

Metamizole sodium, also known as analgin, is banned for use in many countries of the world. Against the background of its intake, there is a high risk of developing agranulocytosis, a condition in which the number of all blood cells decreases sharply.

The patient may die from infection and bleeding. Since 2009, in Russia, metamizole has been excluded from the list of vital funds, but it still remains on sale and is used in some conditions.

Phenobarbital inhibits the activity of the central nervous system. It refers to narcotic drugs and is banned from import into some countries of the world. With prolonged use leads to inhibition of consciousness. Addictive after 2 weeks of admission.

Antispasmodics (papaverine and bendazole) against the background of the other components do not seem so dangerous, but they can also cause unwanted reactions. Most often, there is an upset digestive tract - abdominal pain, constipation.

Another danger of Andipal is an uncontrolled decrease in blood pressure. Taking the drug can lead to hypotension, dizziness, and loss of consciousness.

Kapoten is better tolerated and less likely to cause adverse reactions. Against the background of reception, I can observe the following conditions:

heart rhythm disturbance and tachycardia,

itchy skin and rashes,

drowsiness or insomnia,

nausea, vomiting and abdominal pain,

The Kapoten effect is dose-dependent - the more tablets are taken, the lower the pressure drops and the more often undesirable reactions occur. To reduce the risk of complications, you need to take the drug strictly according to the instructions and do not arbitrarily change the dosage.

Conclusions

Andipal does not apply to drugs that directly affect blood pressure. It relieves symptoms and relaxes blood vessels due to multidirectional effects on the body. Kapoten affects the mechanisms of development of hypertension and precisely reduces pressure.

Andipal acts slowly and is used only with a moderate increase in blood pressure. Kapoten works quickly and is used as a first aid for hypertensive crisis.

Andipal is poorly tolerated, causes severe adverse reactions and is prescribed only in a short course. Kapoten can be used for a long time in the treatment of hypertension and related conditions.

Andipal is cheap, familiar and understandable.For many years, hypertensive patients have been using this drug to relieve unpleasant symptoms and often do not even try to choose another remedy - convenient, effective and relatively safe.

Kapoten can be a good alternative in the treatment of hypertension. He copes well with the task and it is not by chance that he received the recognition of cardiologists. But finally, the choice of the drug is determined by the doctor.

Do not try to treat yourself - this can be life threatening.

Urinary Disorders

Excretion of captopril and hydrochlorothiazide is carried out using the kidneys. Violations in the work of this body (with creatinine clearance of 30-80 ml per 1 minute) lead to an increase in the level of active components of the tablet in serum.

To adjust the dose of active substances to therapeutic indicators, take half a tablet per day, which corresponds to the amount of captopril 25 mg and hydrochlorothiazide 12.5 mg. Usually take the medicine in the morning 1 hour before breakfast.

Application and dosage

Both medicines are available in tablets and do not have complex treatment regimens. "Captopril" is usually prescribed in a dosage of 6.25-12.5 mg twice or thrice a day. With insufficient treatment effectiveness, the dose can be increased to 50 mg 3 p.

/ day, but without the consent of a cardiologist, doing this is strictly contraindicated. As for Andipal, it should be taken 1-2 tablets in the morning, afternoon and evening. The duration of the treatment course is 7-10 days.

Restrictions on use

Despite the high effectiveness of these pharmaceuticals, each of them has contraindications.

So, “Andipal” is not prescribed during the first trimester of pregnancy, with personal intolerance of any component from its composition, breastfeeding and with deviations in the functioning of the kidneys and liver.

There is no compatibility of the combined medication with alcohol, so for the time of therapy it will be necessary to abandon the use of alcohol-containing drinks. It is not recommended to resort to treatment with Andipal for acute pathologies of the hematopoietic system.

Captopril has a larger list of contraindications than Andipal. And it will be required to refuse it in such cases:

  • lactation, gestation,
  • age to 18 years
  • narrowing of the aortic opening in the valve area,
  • coronary artery disease,
  • decrease in blood flow through coronary blood vessels,
  • hypersensitivity to the components of the drug,
  • angioneurotic neurosis,
  • cardiogenic shock
  • elderly age,
  • impaired activity of the kidneys and liver,
  • high potassium in the blood,
  • local swelling of the mucous membranes and subcutaneous tissue.

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This is the same?

Both drugs are used in the treatment of different stages of hypertension and heart failure / They are based on the same active substance - captopril. Medicines are available in 25 and 50 mg doses, which makes it easy to find the optimal dosage.

Kapoten and Captopril are drugs from the group of ACE inhibitors. They slow down the synthesis of angiotensin, prevent vasoconstriction, and prevent sodium and fluid retention in the body. Regular intake improves health, physical activity causes less discomfort, and increases life expectancy.

Important! Capoten and captopril increase cardiac output, but the heart rate does not increase.

Benefits of Captopril and Capoten:

  • reduce the likelihood of developing serious pathologies of the heart and blood vessels,
  • quickly normalize the pressure
  • do not adversely affect male potency,
  • can be taken in old age,
  • have a low price.

Captopril-based drugs act quickly - after half an hour, health is significantly improved. To enhance the effect, the tablet should be placed under the tongue.

Indications for use

The instructions for both drugs indicate in which cases they should be taken. It is necessary to strictly observe the dosages prescribed by the doctor and do not interrupt the treatment yourself.

Indications for use:

  1. Any stages of hypertension and hypertension - drugs are used independently or included in complex therapy. Experts believe that Kapoten is more easily tolerated by the body, especially with prolonged treatment.
  2. Pathological changes in the work of the left ventricle - this condition is often diagnosed after a heart attack. To restore the work of the heart department in full, both drugs are suitable. They are prescribed only after the patient's condition stabilizes.
  3. Nephropathy in diabetes - diabetes mellitus provokes the development of many concomitant diseases, kidney problems in diabetics can be very serious. Kapoten and Captopril are prescribed for an insulin-dependent form of diabetes to normalize kidney function, provided that the level of albuminuria is normal.
  4. Chronic heart failure - with such a disease, long-term therapy is required, therefore both drugs are used alternately.

Kapoten and Captopril are taken one hour before a meal. The tablet can not be chewed, crushed - you just need to drink plenty of water. The volume and frequency of administration is prescribed by the doctor - it depends on the severity of the disease, age, the presence of chronic diseases. The minimum dose is a quarter tablet with a dosage of 25 g, with an interval of 2-4 weeks. It can be increased by 2 times until the necessary therapeutic effect is achieved. The maximum daily dose is 300 mg.

Important! With increasing doses, the effectiveness of the drug does not increase, but adverse reactions are more acute.

Despite the similarity of the drugs, there is some difference between them.

Difference between drugs

Doctors and pharmacists prefer Kapoten, considering it more effective, but clinical comparative trials of these drugs have not been conducted. What is the difference between these drugs?

If we compare the compositions of the drugs, Captopril contains the active substance in almost pure form - the amount of excipients is minimal. Kapoten is a multicomponent drug. It contains certain additives that slightly reduce the manifestation of side effects. But Kapoten contains microcrystalline cellulose, which allows the tablet to dissolve faster and speeds up the absorption process.

What is better at crisis? Both drugs are effectively used as emergency care for hypertensive crisis. But their main task is systemic therapy of the heart and blood vessels. The drugs are addictive, so they should be changed periodically to maintain a therapeutic effect.

Which is cheaper? The difference in price of drugs is significant. The average cost of Captopril is 40-50 rubles. Kapoten costs 200-250 rubles.

There are other analogues of Captopril and Kapoten that are used to treat hypertension:

Important! Kapoten is a patented drug that is produced by only 2 pharmaceutical companies: Russian and American. Captopril is created by many pharmaceutical companies in India, the countries of the former Soviet Union.

Side effects and contraindications

Kapoten is considered a milder drug, but its contraindications are similar to Captopril.

When you can not take drugs based on captopril:

  • individual intolerance,
  • pathological changes in the liver and kidneys,
  • weakened immunity, immunological diseases,
  • hypotension
  • pregnancy, breastfeeding,
  • children under 16 years old.

Kapoten and Captopril are potent drugs, therefore, they have many side effects. The use of drugs without the supervision of a doctor is prohibited.

Important! With an overdose, a sharp decrease in pressure, shock, coma is possible.

Watch the video: How do ACE inhibitors work? (April 2020).